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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Rigau, L. H., Schattling, P., Mian Teo, B., Lynge, M. E. & Stadler, B. M. (2014). Recent Progress of Liposomes in Nanomedicine. Journal of Materials Chemistry B, 2(39), 6686-6691. https://doi.org/10.1039/C4TB00825A

Rafei-Shamsabadi, D., Müller, S., Pfützner, W., Spillner, E., Rueff, F. & Jakob, T. (2014). Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations. Journal of Allergy and Clinical Immunology, 134(2), 493-494. https://doi.org/10.1016/j.jaci.2014.05.035

Berdyugina , S., Santl-Temkiv, T., Finster, K. & Kuhn, J. (2014). Remote detection of biological pigments by spectro-polarimetry.

Peer, D. & Howard, K. (2014). RNA interference-based Therapeutics and Diagnostics. Drug Delivery and Translational Research, 4(1), 1-2. https://doi.org/10.1007/s13346-013-0182-7

Nielsen, K. H. (2014). Samlebåndets historie og kultur. Videnskab.dk. http://videnskab.dk/blog/samlebandets-historie-og-kultur

Hobolth, A. & Jeff, T. (2014). Sampling and summary statistics of endpoint-conditioned paths in DNA sequence evolution. In M.-H. Chen, L. Kuo & P. O. Lewis (Eds.), Bayesian Phylogenetics: Methods, Algorithms, and Applications (1 ed., Vol. 1). CRC Press.

Sükösd, Z., Andersen, E. S. & Lyngsø, R. (2014). SCFGs in RNA secondary structure prediction: a hands-on approach. Methods in Molecular Biology, 1097, 143-62. https://doi.org/10.1007/978-1-62703-709-9__8, https://doi.org/10.1007/978-1-62703-709-9_8

Kjærgaard, R. S. & Andersen, E. S. (2014). Seeing Streptococcus pneumoniae, a Common Killer Bacteria. In K. Ng, J. P. Bowen & S. McDaid (Eds.), EVA London 2014 : Electronic Visualisation and the Arts (pp. 319-323) http://shop.bcs.org/display.asp?K=9781780172859#

Bredehorst, R., Grunwald, T., Ollert, M. W., Schmidt-Weber, C. & Spillner, E. (2014). Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation.

Liu, L., Besenbacher, F. & Dong, MD. (2014). Self-Assembly of DNA Bases via Hydrogen Bonding Studied by Scanning Tunneling Microscopy. In J. Kjems, E. Ferapontova & K. V. Gothelf (Eds.), Nucleic Acid Nanotechnology (pp. 3-21). Springer. https://doi.org/10.1007/978-3-642-38815-6_1

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