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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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De Vrieze, J., Louage, B., Deswarte, K., Zhong, Z., De Coen, R., Van Herck, S., Nuhn, L., Kaas Frich, C., Zelikin, A. N., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., David, S. A. & De Geest, B. G. (2019). Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. Angewandte Chemie - International Edition, 58(43), 15390-15395. https://doi.org/10.1002/anie.201905687

Nielsen, S. B. & Otzen, D. E. (2019). Quartz Crystal Microbalances as Tools for Probing Protein-Membrane Interactions. In J. H. Kleinschmidt (Ed.), Methods in Molecular Biology: Methods and Protocols (Vol. 2003, pp. 31-52). Springer. https://doi.org/10.1007/978-1-4939-9512-7_2

Westberg, M., Etzerodt, M. & Ogilby, P. R. (2019). Rational Design of Genetically Encoded Singlet Oxygen Photosensitizing Proteins. Current Opinion in Structural Biology, 57(August), 56-62. https://doi.org/10.1016/j.sbi.2019.01.025

Zhu, X., Ding, R., Wang, Z., Wang, Y., Guo, X., Song, Z., Wang, Z. & Dong, M. (2019). Recent advances in synthesis and biosensors of two-dimensional MoS₂. Nanotechnology, 30(50), Article 502004. https://doi.org/10.1088/1361-6528/ab42fe

Qian, X. & Städler, B. (2019). Recent Developments in Polydiacetylene-Based Sensors. Chemistry of Materials, 31(4), 1196-1222. https://doi.org/10.1021/acs.chemmater.8b05185

Christensen, L. F. B., Jensen, K. F., Nielsen, J., Vad, B. S., Christiansen, G. & Otzen, D. E. (2019). Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α-Synuclein Fibrillation. ACS Omega, 4(2), 4029-4039. https://doi.org/10.1021/acsomega.8b03590

Bortolini, C., Kartanas, T., Copic, D., Condado Morales, I., Zhang, Y., Challa, P. K., Peter, Q., Jávorfi, T., Hussain, R., Dong, M., Siligardi, G., Knowles, T. P. J. & Charmet, J. (2019). Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism. Lab on a Chip, 19(1), 50-58. https://doi.org/10.1039/c8lc00757h

Eriksen, C. B. (2019). Rezension zu: Östling, Johan; Sandmo, Erling; Larsson Heidenblad, David; Nilsson Hammar, Anna; Nordberg, Kari H. (Hrsg.): Circulation of Knowledge. Explorations in the History of Knowledge. Lund 2018 , ISBN 978-91-88661-28-9. H-Soz-Kult.

Nielsen, K. H. (2019). Røntgen. Weekendavisen, Sektion 4 (Ideer), 10.

Ji, B., Song, J., Wang, D., Kenaan, A., Zhu, Q., Wang, J., Sønderskov, S. M. & Dong, M. (2019). Room Temperature Study of Seeding Growth on Two-Dimensional DNA Nanostructure. Langmuir, 35(11), 4140-4145. https://doi.org/10.1021/acs.langmuir.8b03804

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Kalinka Hansen