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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nielsen, K. H. (2017). The cunning of uncertainty. Book review. https://sagepus.blogspot.dk/2017/09/the-cunning-of-uncertainty-book-review.html

R. Hutchins, B., Eriksen, C. B. & Wolfe, C. T. (2017). The embodied Descartes: Contemporary readings of L'Homme. In D. Antoine-Mahut & S. Gaukroger (Eds.), Descartes' Treatise on Man and its Reception (pp. 287-304). Springer.

Qu, S., Zhong, Y., Shang, R., Zhang, X., Song, W., Kjems, J. & Li, H. (2017). The emerging landscape of circular RNA in life processes. RNA Biology, 14(8), 992-999. https://doi.org/10.1080/15476286.2016.1220473

Christiansen, S. H., Murphy, R. A., Juul-Madsen, K., Fredborg, M., Hvam, M. L., Axelgaard, E., Skovdal, S. M., Meyer, R. L., Sorensen, U. B. S., Moeller, A., Nyengaard, J. R., Norskov-Lauritsen, N., Wang, M., Gadjeva, M., Howard, K. A., Davies, J. C., Petersen, E. & Vorup-Jensen, T. (2017). The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria. Scientific Reports, 7(1), Article 15653. https://doi.org/10.1038/s41598-017-15969-3

Hansen, T. B. & Kjems, J. (2017). The invasion of circRNAs. RNA Biology, 14(8), 973-974. https://doi.org/10.1080/15476286.2017.1360467

Christiansen, S. H., Zhang, X., Juul-Madsen, K., Hvam, M. L., Vad, B. S., Behrens, M. A., Thygesen, I. L., Jalilian, B., Pedersen, J. S., Howard, K., Otzen, D. E. & Vorup-Jensen, T. (2017). The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage. Biochimica et biophysica acta - Biomembranes, 1859(3), 425-437. https://doi.org/10.1016/j.bbamem.2017.01.001

Yang, C., Vu Quang, H., Husum, D. M. U., Tingskov, S. J. H., Vinding, M. S., Nielsen, T., Song, P., Nielsen, N. C., Nørregaard, R. & Kjems, J. (2017). Theranostic poly(lactic-co-glycolic acid) nanoparticle for magnetic resonance/infrared fluorescence bimodal imaging and efficient siRNA delivery to macrophages and its evaluation in a kidney injury model. Nanomedicine: Nanotechnology, Biology and Medicine, 13(8), 2451–2462. https://doi.org/10.1016/j.nano.2017.08.007

Hayes, S., White, T., Boote, C., Kamma-Lorger, C. S., Bell, J., Sorenson, T., Terrill, N., Shebanova, O. & Meek, K. M. (2017). The structural response of the cornea to changes in stromal hydration. Journal of the Royal Society. Interface, 14(131), Article 20170062. https://doi.org/10.1098/rsif.2017.0062

Okholm, A. H. & Kjems, J. (2017). The utility of DNA nanostructures for drug delivery in vivo. Expert Opinion on Drug Delivery, 14(2), 137-139. https://doi.org/10.1080/17425247.2017.1266335

Malmos, K., Blancas-Mejia, L. M., Weber, B., Buchner, J., Ramirez-Alvarado, M., Naiki, H. & Otzen, D. (2017). ThT 101: a primer on the use of thioflavin T to investigate amyloid formation. Amyloid: the Journal of Protein Folding Disorders, 24(1), 1-16. https://doi.org/10.1080/13506129.2017.1304905

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