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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Eriksen, C. B. (2013). Dannelse af liv: Johann Friedrich Blumenbach og forplantningsspørgsmålet i Oplysningstidens livsvidenskaber. Slagmark: tidsskrift for idéhistorie , 67, 143-155.

Nielsen, K. H. (2013). Det bedste og det værste ved peer review. Videnskab.dk. http://videnskab.dk/blog/det-bedste-og-det-vaerste-ved-peer-review

Chen, D., Yao, Y., Wei, Z., Tu, P., Liu, B., Zhang, S. & Dong, M. (2013). Determining the structural preferences of dimannosides through the linkage constraint and hydrogen-bonded network. Computational and Theoretical Chemistry, 1010, 45-52. https://doi.org/10.1016/j.comptc.2013.01.011

Schiølin, K. H. (2013). Det værendes væren og det sociales socius: et bidrag til studiet af ’Heidegger-Latour-forbindelsen’. STS Encounters , 5(2), 1-30. http://www.dasts.dk/wp-content/uploads/Kasper-Schiolin-2013-Det-vaerendes-vaeren-og-det-sociales-socious-1.pdf

Nielsen, T. O., Sorensen, S., Dagnæs-Hansen, F., Kjems, J. & Sørensen, B. S. (2013). Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo. B J C, 108(11), 2291-2298. https://doi.org/10.1038/bjc.2013.247

Rezende, J. R. D., Kjeldsen, K. U., Hubert, C. RJ., Finster, K., Loy, A. & Jørgensen, B. B. (2013). Dispersal of thermophilic Desulfotomaculum endospores into Baltic Sea sediments over thousands of years. I S M E Journal, 7, 72-84. https://doi.org/10.1038/ismej.2012.83

Poser, A., Lohmayer, R., Vogt, C., Knoeller, K., Planer-Friedrich, B., Sorokin, D., Richnow, H.-H. & Finster, K. (2013). Disproportionation of elemental sulfur by haloalkaliphilic bacteria from soda lakes. Extremophiles, 17(6), 1003-1012. https://doi.org/10.1007/s00792-013-0582-0

Marcussen, L. B., Jepsen, M. L., Kristoffersen, E. L., Franch, O., Proszek, J., Ho, Y.-P., Stougaard, M. & Knudsen, B. R. (2013). DNA-Based Sensor for Real-Time Measurement of the Enzymatic Activity of Human Topoisomerase I. Sensors, 13(4), 4017-4028. https://doi.org/10.3390/s130404017

Tørring, T. & Gothelf, K. V. (2013). DNA nanotechnology: a curiosity or a promising technology? F1000Prime Reports, 5(14). https://doi.org/10.12703/P5-14

Kötzler, M. P., Blank, S., Bantleon, F. I., Wienke, M., Spillner, E. & Meyer, B. (2013). Donor assists acceptor binding and catalysis of human α1,6-fucosyltransferase. A C S Chemical Biology, 8(8), 1830-40. https://doi.org/10.1021/cb400140u

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Kalinka Hansen