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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Macchi, F., Hoffmann, S. V., Carlsen, M., Vad, B. S., Imparato, A., Rischel, C. & Otzen, D. (2011). Mechanical stress affects glucagon fibrillation kinetics and fibril structure. Langmuir, 27(20), 12539–12549. https://doi.org/10.1021/la202125c

Wiklund, E. D., Gao, S., Hulf, T., Sibbritt, T., Nair, S., Costea, D. E., Villadsen, S. B., Bakholdt, V., Bramsen, J. B., Sorensne, J. A., Krogdahl, A., Clark, S. J. & Kjems, J. (2011). MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma. PLoS One, 61(1), e27840 (1-11). http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027840

Hua, Y., Duan, S., Murmann, A. E., Larsen, N., Kjems, J., Lund, A. H. & Peter, M. E. (2011). miRConnect:Identifying effector genes of miRNAs and miRNA families in cancer cells. PLoS One, 6(10), e26521. https://doi.org/10.1371/journal.pone.0026521

Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J. & Kjems, J. (2011). miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO Journal, 30(21), 4414-4422. https://doi.org/10.1038/emboj.2011.359

Lokanathan, A. R., Zhang, S., Regina, V. R., Cole, M. A., Ogaki, R., Dong, M., Besenbacher, F., Meyer, R. L., Kingshott, P. & Ogaki, R. (2011). Mixed poly (ethylene glycol) and oligo (ethylene glycol) layers on gold as nonfouling surfaces created by backfilling. Biointerphases, 6(4), 180-188. https://doi.org/10.1116/1.3647506

Lie, M. A., Thomsen, R., Pedersen, C. N. S., Schiøtt, B. & Christensen, M. H. (2011). Molecular Docking with Ligand Attached Water Molecules. Journal of Chemical Information and Modeling, 51(4), 909-917. https://doi.org/10.1021/ci100510m

Sükösd, Z., Knudsen, B., Værum, M., Kjems, J. & Andersen, E. S. (2011). Multithreaded comparative RNA secondary structure prediction using stochastic context-free grammars. BMC Bioinformatics, 12(103). https://doi.org/10.1186/1471-2105-12-103

Nielsen, K. H. (2011). Naturvidenskab på højskole. Videnskab.dk. http://videnskab.dk/blog/naturvidenskab-pa-hojskole

Hoffmann, N., Mittnacht, U., Hartmann, H., Baumer, Y., Kjems, J., Oberhoffner, S. & Schlosshauer, B. (2011). Neuronal and glial responses to siRNA-coated nerve guide implants in vitro. Neuroscience Letters, 494(1), 14-8. https://doi.org/10.1016/j.neulet.2011.02.043

Nielsen, K. H. & Kjærgaard, R. S. (2011). News coverage of climate change in Nature News and ScienceNOW during 2007. Environmental Communication, 5(1), 25-44. https://doi.org/10.1080/17524032.2010.520722

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Kalinka Hansen