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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Rosen, C. B., Tørring, T. & Gothelf, K. V. (2014). DNA-Templated Synthesis: in Nucleic Acid Nanotechnology, Nucleic Acids and Molecular Biology. In J. Kjems, E. Ferapontova & K. V. Gothelf (Eds.), Nucleic Acid Nanotechnology (Vol. 29). Springer. https://doi.org/10.1007/978-3-642-38815-6_7

Nielsen, K. H. (2014). Dommedag som kold-krigs-konstruktion. Videnskab.dk. http://videnskab.dk/blog/dommedag-som-kold-krigs-konstruktion

Andersen, L. N., Mailund, T. & Hobolth, A. (2014). Efficient computation in the IM model. Journal of Mathematical Biology, 68(6), 1423-1451. https://doi.org/10.1007/s00285-013-0671-9

Lopes, P., Dyrnesli, H., Lorenzen, N., Otzen, D. & Ferapontova, E. (2014). Electrochemical Analysis of the Fibrillation of Parkinson's Disease α-synuclein. Analyst, 139(4), 749-756. https://doi.org/10.1039/C3AN01616A

Chen, M., Li, Y. & Besenbacher, F. (2014). Electrospun nanofibers-mediated on-demand drug release. Advanced Healthcare Materials, 3(11), 1721-1732. https://doi.org/10.1002/adhm.201400166

Femenias, M. R., Dehli, J., Li, Y., Taskin, M. B., Xu, R., Besenbacher, F. & Chen, M. (2014). Electrospun PCL/PEO Coaxial Fibers for basic Fibroblast Growth Factor Delivery. Journal of Materials Chemistry B, 2(48), 8538-8546. https://doi.org/10.1039/C4TB01258E

Mendes, A. C. & Zelikin, A. N. (2014). Enzyme prodrug therapy engineered into biomaterials. Advanced Functional Materials, 24(33), 5202-5210. https://doi.org/10.1002/adfm.201304312

Song, J. J., Zhang, Z. Z., Zhang, S. S., Liu, L. L., Li, Q. Q., Xie, E. E., Gothelf, K. V. K. V., Besenbacher, F. F. & Dong, MD. (2014). Erratum: Isothermal hybridization kinetics of DNA assembly of two-dimensional DNA origami (Small (2013) 17 (2954-2959) DOI: 10.1002/smll.201202861). Small, 10(4), 630. https://doi.org/10.1002/smll.201303931

Eriksen, C. B., Sefland Pedersen, S., Høgh Ipland, S., Jacek, K. M. & Krogh Madsen, J. (Eds.) (2014). Et stykke oplysning: En antologi om viden. Baggrund. http://baggrund.com/et-stykke-oplysning/

Song, J., Li, Q., Wang, X., Li, J., Zhang, S., Kjems, J., Besenbacher, F. & Dong, M. (2014). Evidence of Stranski-Krastanov growth at the initial stage of atmospheric water condensation. Nature Communications, 5, 1-8. Article 4837. https://doi.org/10.1038/ncomms5837

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Kalinka Hansen