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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Ke, P. C., Zhou, R., Serpell, L. C., Riek, R., Knowles, T. P. J., Lashuel, H. A., Gazit, E., Hamley, I. W., Davis, T. P., Fändrich, M., Otzen, D. E., Chapman, M. R., Dobson, C. M., Eisenberg, D. S. & Mezzenga, R. (2020). Half a century of amyloids: past, present and future. Chemical Society Reviews, 49(15), 5473-5509. https://doi.org/10.1039/c9cs00199a

Fang, X., Wang, Z., Kang, S., Zhao, L., Jiang, Z. & Dong, M. (2020). Hexagonal CoSe₂ nanosheets stabilized by nitrogen-doped reduced graphene oxide for efficient hydrogen evolution reaction. International Journal of Hydrogen Energy, 45(3), 1738-1747. https://doi.org/10.1016/j.ijhydene.2019.11.059

Nielsen, K. H. (2020). Hvem tilhører Den Gamle? Weekendavisen, (Sektion 4 (Ideer)), 5.

Feng, Q., Hong, Y., Pradeep Nidamanuri, N., Yang, C., Li, Q. & Dong, M. (2020). Identification and Nanomechanical Characterization of the HIV Tat-Amyloid β Peptide Multifibrillar Structures. Chemistry - A European Journal, 26(43), 9449-9453. https://doi.org/10.1002/chem.201905715

Li, Y., Nidamanuri, N. P., Jiang, A., Wang, Z., Li, Q. & Dong, M. (2020). In situ construction of tandem nitrogen-doped MoP nanocrystals for high-efficient electrocatalytic hydrogen evolution. Electrochimica Acta, 342, Article 136059. https://doi.org/10.1016/j.electacta.2020.136059

Omer, M., Andersen, V. L., Nielsen, J. S., Wengel, J. & Kjems, J. (2020). Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds. Molecular Therapy - Nucleic Acids, 22, 994-1003. https://doi.org/10.1016/j.omtn.2020.10.013

Li, D., Sun, X., Gao, C. & Dong, M. (2020). Improved water flux and antifouling properties of cardo poly(aryl ether ketone) ultrafiltration membrane by novel sulfobetaine polyimides additive. Separation and Purification Technology, 251, Article 117144. https://doi.org/10.1016/j.seppur.2020.117144

Conzelmann, C., Müller, J. A., Perkhofer, L., Sparrer, K. M. J., Zelikin, A. N., Münch, J. & Kleger, A. (2020). Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Clinical Medicine, 20(6), e218-e221. https://doi.org/10.7861/clinmed.2020-0351

Eskandari, H., Ghanadian, M., Noleto-Dias, C., Lomax, C., Tawfike, A., Christiansen, G., Sutherland, D. S., Ward, J. L., Mohammad-Beigi, H. & Otzen, D. E. (2020). Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides. ACS Chemical Neuroscience, 11(19), 3161–3173. https://doi.org/10.1021/acschemneuro.0c00528

Strecker, C., Bärenfänger, M., Miehe, M., Spillner, E. & Meyer, B. (2020). In Silico Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to Synthesize an Inhibitor with Drug-Like Properties. ChemBioChem, 21(13), 1923-1931. https://doi.org/10.1002/cbic.201900289

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