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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M. (2019). Strontium functionalized scaffold for bone tissue engineering. Materials Science and Engineering C, 94, 509-515. https://doi.org/10.1016/j.msec.2018.09.054

Timcenko, M., Lyons, J. A., Januliene, D., Ulstrup, J. J., Dieudonné, T., Montigny, C., Ash, M. R., Karlsen, J. L., Boesen, T., Kühlbrandt, W., Lenoir, G., Moeller, A. & Nissen, P. (2019). Structure and autoregulation of a P4-ATPase lipid flippase. Nature, 571(7765), 366-370. https://doi.org/10.1038/s41586-019-1344-7

Ye, J., Jin, L., Zhao, X., Qian, X. & Dong, M. (2019). Superior adsorption performance of metal-organic-frameworks derived magnetic cobalt-embedded carbon microrods for triphenylmethane dyes. Journal of Colloid and Interface Science, 536, 483-492. https://doi.org/10.1016/j.jcis.2018.10.073

Kang, S., He, M., Chen, M., Liu, Y., Wang, Y., Wang, Y., Dong, M., Chang, X. & Cui, L. (2019). Surface Amino Group Regulation and Structural Engineering of Graphitic Carbon Nitride with Enhanced Photocatalytic Activity by Ultrafast Ammonia Plasma Immersion Modification. ACS Applied Materials & Interfaces, 11(16), 14952-14959. https://doi.org/10.1021/acsami.9b01068

Xu, R., Zhang, Z., Toftdal, M. S., Møller, A. C., Dagnaes-Hansen, F., Dong, M., Thomsen, J. S., Brüel, A. & Chen, M. (2019). Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis. Journal of Controlled Release, 301, 129-139. https://doi.org/10.1016/j.jconrel.2019.02.037

Nielsen, K. H. (2019). Synspunkt: 11.258 forskere kan godt tage fejl. Aktuel Naturvidenskab, 2019(6), 2. https://aktuelnaturvidenskab.dk/fileadmin/Aktuel_Naturvidenskab/nr-6/AN6-2019synspunkt.pdf

Nielsen, K. H. (2019). Tænkepause. In Tag en pause (pp. 5-7). Aarhus Universitetsforlag.

Nielsen, K. H. (2019). Taking citizenship seriously in citizen science. Abstract from Citizen science, Lyon, France. https://www.partiscip.com/wp-content/uploads/2019/05/Booklet-2.pdf

Kristensen, L. S., Schertz Andersen, M., Stagsted, L. V. W., Ebbesen, K., Hansen, T. B. & Kjems, J. (2019). The biogenesis, biology and characterization of circular RNAs. Nature Reviews. Genetics, 20(11), 675-691. https://doi.org/10.1038/s41576-019-0158-7

Jin, H., Zhang, Z., Zhang, Z., Chim, P. O., Liu, L. & Dong, MD. (2019). The Effect of 2D Van der Waals Materials on the Photoresponse of Upconversion Nanoparticles. Journal of Self-Assembly and Molecular Electronics, 7(1), 73-86. https://doi.org/10.13052/jsame2245-4551.7.004

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Kalinka Hansen