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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Fowler, P. W., Orwick-Rydmark, M., Radestock, S., Solcan, N., Dijkman, P. M., Lyons, J. A., Kwok, J., Caffrey, M., Watts, A., Forrest, L. R. & Newstead, S. (2015). Gating topology of the proton-coupled oligopeptide symporters. Structure, 23(2), 290-301. https://doi.org/10.1016/j.str.2014.12.012

Nielsen, K. H. (2015). Gen. Weekendavisen, Ideer, 10.

Guo, Q., Xue, Q., Sun, J., Dong, M., Xia, F. & Zhang, Z. (2015). Gigantic enhancement in the dielectric properties of polymer-based composites using core/shell MWCNT/amorphous carbon nanohybrids. Nanoscale, 7(8), 3660-3667. https://doi.org/10.1039/c4nr05264a

Kyhl, L., Nielsen, S. F., Cabo, A. G., Cassidy, A., Miwa, J. A. & Hornekær, L. (2015). Graphene as an anti-corrosion coating layer. Faraday Discussions, 180, 495-509. https://doi.org/10.1039/c4fd00259h

Nielsen, K. H. (2015). Grønlands Tekniske Organisation. Videnskab.dk. http://videnskab.dk/blog/gronlands-tekniske-organisation

Ruiz-Sanchis, P., Wohl, B. M., Smith, A. A. A., Zuwala, K., Melchjorsen, J., Tolstrup, M. & Zelikin, A. N. (2015). Highly active macromolecular prodrugs inhibit expression of the hepatitis c virus genome in the host cells. Advanced Healthcare Materials, 4(1), 65-68. https://doi.org/10.1002/adhm.201400307

Xu, R., Taskin, M. B., Rubert, M., Seliktar, D., Besenbacher, F. & Chen, M. (2015). hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold. Scientific Reports, 5, 1-7. Article 8480. https://doi.org/10.1038/srep08480

Finster, K. (2015, Apr 16). Hvordan kan liv i rummet se ud? http://videnskab.dk/sporg-videnskaben/hvordan-kan-liv-i-rummet-se-ud

Nielsen, K. H. (2015). Hybride afgrøder. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 201-205). Aarhus Universitetsforlag.