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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Liang, H., Zeng, G., Li, Y., Zhang, S., Zhao, H., Guo, L., Liu, B. & Dong, MD. (2014). Exploring the complex mechanical properties of xanthan scaffolds by AFM-based force spectroscopy. Beilstein Journal of Nanotechnology, 5, 365-373. https://doi.org/10.3762/bjnano.5.42

Ebbesen, M., Bienk, K., Deleuran, B. W. & Howard, K. (2014). Extended blood circulation and accumulation of a p(HPMA-co-AzMA)-based nanoconjugate in a murine model of rheumatoid arthritis. Molecular and Cellular Therapies, 2(29). https://doi.org/10.1186/2052-8426-2-29

Ebbesen, M. F., Bienk, K., Deleuran, B. W. & Howard, K. (2014). Extended circulation and accumulation of p(HPMA-co-AzMA) and accumulation in arthritic joints. Poster session presented at 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014 Chicago, USA , Chicago, United States.

Rastian, Z., Khodadadi, A. A., Vahabzadeh, F., Bortolini, C., Dong, MD., Mortazavi, Y., Mogharei, A., Naseh, M. V. & Guo, Z. (2014). Facile surface functionalization of multiwalled carbon nanotubes by soft dielectric barrier discharge plasma: Generate compatible interface for lipase immobilization. Biochemical Engineering Journal, 90, 16-26. https://doi.org/10.1016/j.bej.2014.05.009

Heymann, M. & Nielsen, K. H. (2014). Fæstning Grønland: Videnskab og teknologi under den kolde krig. Carlsbergfondet. Aarsskrift, 46-49. http://online.fliphtml5.com/xsvh/eaqy/

Nielsen, K. H. (2014). Fagets videnskabsteori: nu med heste og høns. Videnskab.dk. http://videnskab.dk/blog/fagets-videnskabsteori-nu-med-heste-og-hons

Okholm, A., Kjems, J. & Astakhova, K. (2014). Fluorescence detection of natural RNA using rationally designed "clickable" oligonucleotide probes. RSC Advances, 4(86), 45653-45656. https://doi.org/10.1039/c4ra07165d

Neumann, J., Klein, N., Otzen, D. & Schneider, D. (2014). Folding energetics and oligomerization of polytopic α-helical transmembrane proteins. Archives of Biochemistry and Biophysics, 564, 281–296. https://doi.org/10.1016/j.abb.2014.07.017

Andersen, K. K. & Otzen, D. (2014). Folding of outer membrane protein A in the anionic biosurfactant rhamnolipid. FEBS Letters, 588(10), 1955-1960. https://doi.org/10.1016/j.febslet.2014.04.004

Yang, C., Gao, S. & Kjems, J. (2014). Folic Acid Conjugated Chitosan for Targeted Delivery of siRNA to Activated Macrophages in vitro and in vivo. Journal of Materials Chemistry B, 48, 8608-8615. https://doi.org/10.1039/C4TB01374C

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Kalinka Hansen