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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nielsen, K. H. (2010). Scientists' Understanding of the Public. In S. H. Priest (Ed.), Encyclopedia of Science and Technology (pp. 782-785). SAGE Publications.

Giehm, L., Oliveira, C. L. P. D., Christiansen, G., Pedersen, J. S. & Otzen, D. (2010). SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway. Journal of Molecular Biology, 401, 115-133. https://doi.org/10.1016/j.jmb.2010.05.060

Dupont, D. M., Madsen, J. B., Hartmann, R. K., Tavitian, B., Ducongé, F., Kjems, J. & Andreasen, P. A. (2010). Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA, 16(12), 2360-9. https://doi.org/10.1261/rna.2338210

Helmig, S. W., Rotaru, A., Arian, D., Kovbasyuk, L., Arnbjerg, J., Ogilby, P. R., Kjems, J., Mokhir, A., Besenbacher, F. & Gothelf, K. V. (2010). Single Molecule Atomic Force Microscopy Studies of Photosensitized Singlet Oxygen Behavior on a DNA Origami Template. A C S Nano, 4(12), 7475-7480. https://doi.org/10.1021/nn102701f

Voigt, N. V., Tørring, T., Rotaru, A., Jacobsen, M. F., Ravnsbæk, J. B., Subramani, R., Mamdouh, W., Kjems, J., Mokhir, A., Besenbacher, F. & Gothelf, K. V. (2010). Single-molecule chemical reactions on DNA origami. Nature Nanotechnology, 5(3), 200-203. https://doi.org/10.1038/nnano.2010.5

Andersen, M. Ø., Nygaard, J. V., Burns, J. S., Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J. (2010). siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells. Molecular Therapy, 18(11), 2018-2027. https://doi.org/10.1038/mt.2010.166

Nielsen, K. H. (2010). Sixth Framework Programme. In D. H. Guston (Ed.), Encyclopedia of Nanotechnology and Society (pp. 717-718). SAGE Publications.

Nielsen, K. H. & Thomasen, L. S. (2010). Smilla, Anna og Alexandra: Videnskabskvinder i nyere dansk populærlitteratur. Slagmark: tidsskrift for idéhistorie , 58, 85-98.

Knudsen, M., Feliu, E., Wiuf, C. H. & Andersen, L. N. (2010). Steady States of Phosphorelays and Two-Component Systems. Poster session presented at The 11th International Conference on Systems Biology, Edinburgh, United Kingdom.

Binder, M., Léchenne, B., Ummanni, R., Balabanov, S., Trepel, M., Scharf, C., Trusch, M., Schlüter, H., Braren, I. & Spillner, E. (2010). Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells. PLoS One, 5(12), Article e15992. https://doi.org/10.1371/journal.pone.0015992

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