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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Pérez, B., Dahlgaard, S. E., Bulsara, P., Jensen, M. M., Dong, MD., Glasius, M., Clarke, M. J. & Guo, Z. (2017). Synthesis and characterization of O-acylated-ω-hydroxy fatty acids as skin-protecting barrier lipids. Journal of Colloid and Interface Science, 490, 137-146. https://doi.org/10.1016/j.jcis.2016.11.031

Villadsen, N. L., Jacobsen, K. M., Keiding, U., Tørring, T. & Poulsen, T. (2017). Synthesis of ent-BE-43547A1 Reveals a Potent Hypoxia-Selective Anticancer Agent and Uncovers the Biosynthetic Origin of the APDCLD Natural Products. Synfact, 2017(7), A107-111. https://doi.org/10.1055/s-0036-1590288

Villadsen, N. L., Jacobsen, K. M., Keiding, U., Weibel, E. T., Christiansen, B., Vosegaard, T., Bjerring, M., Jensen, F., Johannsen, M., Tørring, T. & Poulsen, T. (2017). Synthesis of ent-BE-43547A₁ reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products. Nature Chemistry, 9(3), 264-272. https://doi.org/10.1038/nchem.2657

Jin, L., Zhao, X., Qian, X., Wang, S., Shen, X. & Dong, M. (2017). Synthesis of porous In₂O₃/carbon composites derived from metal-organic frameworks for high performance Li-ion batteries. Materials Letters, 199, 176-179. https://doi.org/10.1016/j.matlet.2017.04.016

Riber, C. F., Halling Folkmar Andersen, A., Anegaard Rolskov, L., Zuwala, K., Gajda, P., Borup Løvschall, K., Dagnæs-Hansen, F., Banda, D. H., Pietschmann, T., Tolstrup, M. & Zelikin, A. N. (2017). Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells. ACS Macro Letters, 6(935-940), 935-940. https://doi.org/10.1021/acsmacrolett.7b00471

Sørensen, H. V., Pedersen, J. N., Pedersen, J. S. & Otzen, D. E. (2017). Tailoring thermal treatment to form liprotide complexes between oleic acid and different proteins. Biochimica et Biophysica Acta - Proteins and Proteomics, 1865(6), 682–693. https://doi.org/10.1016/j.bbapap.2017.03.011

Westberg, M., Bregnhøj, M., Etzerodt, M. & Ogilby, P. R. (2017). Temperature Sensitive Singlet Oxygen Photosensitization by LOV-Derived Fluorescent Flavoproteins. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 121(12), 2561-2574. https://doi.org/10.1021/acs.jpcb.7b00561

Su, Y., Ma, S., Zhao, X., Dong, M. & Han, X. (2017). Template-free synthesis of inorganic hollow spheres at water/"water-brother" interfaces as Fenton-like reagents for water treatment. Journal of Environmental Sciences, 55, 331-338. https://doi.org/10.1016/j.jes.2016.10.012

Nielsen, K. H. (2017). Terror. Weekendavisen, Sektion 4 (Ideer), 10.

Malmos, K. G., Stenvang, M., Sahin, C., Christiansen, G. & Otzen, D. E. (2017). The Changing Face of Aging: Highly Sulfated Glycosaminoglycans Induce Amyloid Formation in a Lattice Corneal Dystrophy Model Protein. Journal of Molecular Biology, 429(18), 2755-2764. https://doi.org/10.1016/j.jmb.2017.07.014

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Kalinka Hansen