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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Li, Y., Liu, L., Subramani, R., Pan, Y., Liu, B., Yang, Y., Wang, C., Mamdouh, W., Besenbacher, F. & Dong, M. (2011). Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface. Chemical Communications, 47(32), 9155-9157. https://doi.org/10.1039/c1cc11443c

Yao, Y., Chen, D., Zhang, S., Li, Y., Tu, P., Liu, B. & Dong, M. (2011). Building the first hydration shell of deprotonated glycine by the MCMM and ab initio methods. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 115(19), 6213-21. https://doi.org/10.1021/jp1117097

Nygaard, J. V., Uyar, T., Chen, M., Cloetens, P., Kingshott, P. & Besenbacher, F. (2011). Characterisation of internal morphologies in electrospun fibers by X-ray tomographic microscopy. Nanoscale, 3. https://doi.org/10.1039/c1nr10304k

Bramsen, J. B. & Kjems, J. (2011). Chemical modification of small interfering RNA. Methods in Molecular Biology, 721(1), 77-103. https://doi.org/10.1007/978-1-61779-037-9_5

Nielsen, K. H. (2011). City under the Ice: The Closed World of Camp Century. Abstract from HSS Annual Meeting, Cleveland, OH, United States. http://www.hssonline.org/Meeting/2011HSSMeeting/Program%20Abstracts.pdf

Locke, D. P., Hillier, L. W., Warren, W. C., Yang, S.-P., Wang, Z., Chinwalla, A. T., Minx, P., Mitreva, M., Cook, L., Delehaunty, K. D., Fronick, C., Schmidt, H., Fulton, L. A., Fulton, R. S., Nelson, J. O., Magrini, V., Pohl, C., Graves, T. A., Markovic, C. ... de Jong, P. J. (2011). Comparative and demographic analysis of orang-utan genomes. Nature, 469, 529-533. https://doi.org/10.1038/nature09687

Tataru, P. C. & Hobolth, A. (2011). Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains. BMC Bioinformatics, 12(1), 465. https://doi.org/10.1186/1471-2105-12-465

Jepsen, M. DE., Beerens, N., Besenbacher, F., Kjems, J. & Birkedal, V. (2011). Conformational changes of HIV-1 RNA upon tRNA primer annealing studied by ensemble and single-molecule FRET.

Tørring, T. (2011). Controlling Function and Structure with DNA.