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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Basse-O'Connor, A., Nielsen, M. S. & Pedersen, J. (2018). Equivalent martingale measures for Lévy-driven moving averages and related processes. Stochastic Processes and Their Applications, 128(8), 2538-2556. https://doi.org/10.1016/j.spa.2017.09.022

Jepsen, M. D. E., Sparvath, S. M., Nielsen, T. B., Langvad, A. H., Grossi, G., Gothelf, K. V. & Andersen, E. S. (2018). Erratum: Publisher Correction: Development of a genetically encodable FRET system using fluorescent RNA aptamers (Nature communications (2018) 9 1 (18)). Nature Communications, 9(1), Article 669. https://doi.org/10.1038/s41467-018-03075-5

Bladt, T. M., Vorup-Jensen, T., Sædder, E. A. & Ebbesen, M. (2018). Etiske perspektiver på diskussionen om fordeling af ressourcer i det danske sundhedsvæsen. Ugeskrift for Læger, 22/2018. http://ugeskriftet.dk/debat/etiske-perspektiver-pa-diskussionen-om-fordeling-af-ressourcer-i-det-danske-sundhedsvaesen

Kyhl, L., Bisson, R., Balog, R., Groves, M. N., Kolsbjerg, E. L., Cassidy, A. M., Jørgensen, J. H., Halkjær, S., Miwa, J. A., Čabo, A. G., Angot, T., Hofmann, P., Arman, M. A., Urpelainen, S., Lacovig, P., Bignardi, L., Bluhm, H., Knudsen, J., Hammer, B. & Hornekaer, L. (2018). Exciting H2 Molecules for Graphene Functionalization. ACS Nano, 12(1), 513-520. https://doi.org/10.1021/acsnano.7b07079

Adam, V., Prusty, D. K., Centola, M., Škugor, M., Hannam, J. S., Valero Moreno, J., Klôckner, B. & Famulok, M. (2018). Expanding the Toolbox of Photoswitches for DNA Nanotechnology Using Arylazopyrazoles. Chemistry - A European Journal, 24(5), 1062-1066. https://doi.org/10.1002/chem.201705500

Gu, Z., Plant, L. D., Meng, X.-Y., Perez-Aguilar, J. M., Wang, Z., Dong, M., Logothetis, D. E. & Zhou, R. (2018). Exploring the Nanotoxicology of MoS₂: A Study on the Interaction of MoS₂Nanoflakes and K⁺ Channels. A C S Nano, 12(1), 705-717. https://doi.org/10.1021/acsnano.7b07871

Nielsen, K. H. (2018). Feminisme. Weekendavisen, Sektion 4 (Ideer), 10.

Xu, R., Dagnæs-Hansen, F., Bach, L. W., Axelsen, S. M., Seliktar, D. & Chen, M. (2018). Fibrogenic and angiogenic commitments of human induced pluripotent stem cells derived mesenchymal stem cells in connective tissue growth factor-delivering scaffold in an immune-deficient mice model. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 106(6), 2266-2274. https://doi.org/10.1002/jbm.b.34030

Zhang, P., Yang, X., Gao, W., Hou, X., Mi, J., Liu, L., Huang, J., Dong, M. & Stampfl, C. (2018). First-principles design of bifunctional oxygen reduction and evolution catalysts through bimetallic centers in metal-organic frameworks. Catalysis Science and Technology, 8(14), 3666-3674. https://doi.org/10.1039/c8cy00675j

Nielsen, K. H. (2018). Fodbold. Weekendavisen, Sektion 4 (Ideer), 10.

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Kalinka Hansen