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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Marcussen, L. B., Jepsen, M. L., Kristoffersen, E. L., Franch, O., Proszek, J., Ho, Y.-P., Stougaard, M. & Knudsen, B. R. (2013). DNA-Based Sensor for Real-Time Measurement of the Enzymatic Activity of Human Topoisomerase I. Sensors, 13(4), 4017-4028. https://doi.org/10.3390/s130404017

Tørring, T. & Gothelf, K. V. (2013). DNA nanotechnology: a curiosity or a promising technology? F1000Prime Reports, 5(14). https://doi.org/10.12703/P5-14

Kötzler, M. P., Blank, S., Bantleon, F. I., Wienke, M., Spillner, E. & Meyer, B. (2013). Donor assists acceptor binding and catalysis of human α1,6-fucosyltransferase. A C S Chemical Biology, 8(8), 1830-40. https://doi.org/10.1021/cb400140u

Brodal, G. S., Fagerberg, R., Mailund, T., Pedersen, C. N. S. & Sand, A. (2013). Efficient Algorithms for Computing the Triplet and Quartet Distance Between Trees of Arbitrary Degree. The Annual A C M - S I A M Symposium on Discrete Algorithms. Proceedings, 24, 1814-1832. http://knowledgecenter.siam.org/0236-000098/0236-000098/1

Lopes, P., Dyrnesli, H., Lorenzen, N., Otzen, D. & Ferapontova, E. (2013). Electroanalysis of Amyloid Formation of Parkinson's Disease alpha-Synuclein. Abstract from 6th International Workshop on Surface Modification for Chemical and Biochemical Sensing, Warsaw, Poland.

Ulstrup, S., Nilsson, L., Miwa, J. A., Balog, R., Bianchi, M., Hornekær, L. & Hofmann, P. (2013). Electronic structure of graphene on a reconstructed Pt(100) surface: Hydrogen adsorption, doping, and band gaps. Physical Review B - Condensed Matter and Materials Physics, 88(12). https://doi.org/10.1103/PhysRevB.88.125425

Christian Johannsen, J., Ulstrup, S., Bianchi, M., Hatch, R., Guan, D., Mazzola, F., Hornekær, L., Fromm, F., Raidel, C., Seyller, T. & Hofmann, P. (2013). Electron-phonon coupling in quasi free-standing graphene. Journal of Physics: Condensed Matter, 25, 094001. https://doi.org/10.1088/0953-8984/25/9/094001

Chen, M., Nielsen, S. R., Uyar, T., Zhang, S., Zafar, A., Dong, M. & Besenbacher, F. (2013). Electrospun UV-responsive supramolecular nanofibers from a cyclodextrin–azobenzene inclusion complex. Journal of Materials Chemistry, Part C(1), 850-855. https://doi.org/10.1039/c2tc00180b

Kang, R., Svend Le, D. Q., Li, H., Lysdahl, H., Chen, M., Besenbacher, F. & Bünger, C. (2013). Engineered three-dimensional nanofibrous multi-lamellar structure for annulus fibrosus repair. Journal of Materials Chemistry B, 1(40), 5462-5468. https://doi.org/10.1039/c3tb20562b, https://doi.org/10.1039/c3tb20562b

Bramsen, J. B. & Kjems, J. (2013). Engineering small interfering RNAs by strategic chemical modification. In D. J. Taxman (Ed.), siRNA design: methods and protocols (pp. 87-109). Springer. https://doi.org/10.1007/978-1-62703-119-6_5

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Kalinka Hansen