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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Eriksen, C. B. (2012). Kød - eller sjæl, som min datter siger: om Diderots vitalistiske materialisme. Semikolon (Aarhus C), 13(24), 35-42.

Nielsen, K. H. (2012). Kulstof-demokrati 2. Videnskab.dk. http://videnskab.dk/blog/kulstof-demokrati-2

Otzen, D., Blans, K., Wang, H., Gilbert, G. E. & Rasmussen, J. T. (2012). Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition. BBA General Subjects, 1818(4), 1019-1027. https://doi.org/10.1016/j.bbamem.2011.08.032

Nilsson, L., Sljivancanin, Z., Balog, R., Xu, W., Linderoth, T. R., Lægsgaard, E., Stensgaard, I., Hammer, B., Besenbacher, F. & Hornekær, L. (2012). Linear hydrogen adsorbate structures on graphite induced by self-assembled molecular monolayers. Carbon, 50(5), 2052–2056. https://doi.org/10.1016/j.carbon.2011.12.050,

Smith, A. A. A., Hussmann, T., Elich, J., Alves, M.-H., Postma, A. & Zelikin, A. N. (2012). Macromolecular design of poly(vinyl alcohol) by RAFT polymerization. Polymer Chemistry, 3(1), 85-88. https://doi.org/10.1039/c1py00429h

Shimoni, O., Postma, A., Yan, Y., Scott, A. M., Heath, J. K., Nice, E. C., Zelikin, A. N. & Caruso, F. (2012). Macromolecule Functionalization of Disulfide-Bonded Polymer Hydrogel Capsules and Cancer Cell Targeting. A C S Nano, 6(2), 1463-1472. https://doi.org/10.1021/nn204319b

Šljivančanin, Ž., Balog, R. & Hornekær, L. (2012). Magnetism in graphene induced by hydrogen adsorbates. Chemical Physics Letters, 541, 70-74. https://doi.org/10.1016/j.cplett.2012.05.043

Calcutta, A., Jessen, C. M., Behrens, M. A., Oliveira, C. L. P., Renart, M. L., González-Ros, J. M., Otzen, D., Pedersen, J. S., Malmendal, A. & Nielsen, N. C. (2012). Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant. Biochimica et biophysica acta - Biomembranes, 1818(9), 2290-301. https://doi.org/10.1016/j.bbamem.2012.04.005

Ghodke, S., Nielsen, S. B., Christiansen, G., Hjuler, H. A., Flink, J., Otzen, D. & Nielsen, S. B. (2012). Mapping out the multistage fibrillation of glucagon. FEBS journal, 279(5), 752-765. https://doi.org/10.1111/j.1742-4658.2011.08465.x

Asmussen, S. & Hobolth, A. (2012). Markov bridges, bisection and variance reduction. In L. Plaskota & H. Wozniakowski (Eds.), Monte Carlo and Quasi-Monte Carlo Methods 2010 (pp. 3-22). Springer. https://doi.org/10.1007/978-3-642-27440-4_1

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Kalinka Hansen