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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Qin, R., Bai, M., Zhang, F., Wang, Z., Liu, F., Dong, M., Liu, L. & Xu, J. (2025). Optimized multifunctional peptide based magnetic biointerface for selective capture and sensitive detection of circulating tumor cells in breast cancer. Sensors and Actuators B: Chemical, 442, Article 138059. https://doi.org/10.1016/j.snb.2025.138059

Einarsson, H. B., Mortensen, A. F., Nielsen, M. S., Chen, M., Nielsen, S. R., Kraft, D. C. E., Jensen, J., Bjerre, M., Nygaard, J. V., Bünger, C. E. & Vorup-Jensen, T. (2025). Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts. Frontiers in Immunology, 16, Article 1572238. https://doi.org/10.3389/fimmu.2025.1572238

Rasmussen, M. H., Møller, S. L. B., Svenningsen, E. B., Tørring, T. & Poulsen, T. B. (2025). P450 Enzyme LyoI Performs Hydro-2,2'-Bifuran Oxidation in the Polyether Ionophore Lysocellin. Angewandte Chemie International Edition, 64(43), Article e202507847. https://doi.org/10.1002/anie.202507847

Jain, S., de Freitas, B. N., Basse-OConnor, A., Iosifidis, A. & Pauwels, R. (2025). PanoDiff-SR: Synthesizing Dental Panoramic Radiographs using Diffusion and Super-resolution.

Mirab, F., Pirhaghi, M., Otzen, D. E. & Saboury, A. A. (2025). Parkinson's disease and gut microbiota metabolites: The dual impact of vitamins and functional amyloids. B B A - Molecular Basis of Disease, 1871(6), Article 167862. https://doi.org/10.1016/j.bbadis.2025.167862

Mishra, A., Golbek, T. W., Thomassen, A. B., Zuzic, L., Schmüser, L., Saeed, K. H., Madzharova, F., Nielsen, J., Schiøtt, B., Otzen, D. E. & Weidner, T. (2025). Pathological Folding of α-Synuclein on Polystyrene Nanoplastic Revealed by Sum Frequency Scattering and 2D Infrared Spectroscopy. The Journal of Physical Chemistry Letters, 16(45), 11893-11900. https://doi.org/10.1021/acs.jpclett.5c02526

Jansen, S. A. H., Dreyer, L. S. A., van Basten, J., Yao, Y., Otzen, D. E., de Greef, T. F. A., Knowles, T. P. J., Meijer, E. W. & Erkamp, N. A. (2025). PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning. ACS Nano, 19(45), 38981-38989. https://doi.org/10.1021/acsnano.5c07268

Amir, G., Heydenreich, M. & Hirsch, C. (2025). Planar reinforced k-out percolation. Stochastic Processes and Their Applications, 189, Article 104706. https://doi.org/10.1016/j.spa.2025.104706

Nielsen, K. H. (2025). Platon mod poeterne. Weekendavisen, Sektion 4 (Ideer), 5.

Hirsch, C., Jahnel, B., Jhawar, S. K. & Juhasz, P. (2025). Poisson approximation of fixed-degree nodes in weighted random connection models. Stochastic Processes and Their Applications, 183, Article 104593. https://doi.org/10.1016/j.spa.2025.104593

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Kalinka Hansen