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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Marvian, A. T., Aliakbari, F., Mohammad-Beigi, H., Ahmadi, Z. A., Mehrpouyan, S., Lermyte, F., Nasouti, M., Collingwood, J. F., Otzen, D. E. & Morshedi, D. (2020). The status of the terminal regions of α-synuclein in different forms of aggregates during fibrillization. International Journal of Biological Macromolecules, 155, 543-550. https://doi.org/10.1016/j.ijbiomac.2020.03.238

Su, Y., Zhang, E., Wang, Y., Li, Q., Chen, M. & Dong, MD. (2020). Tunable Hierarchical Wrinkling Surface via Microscale Patterned Vertical Deformation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 607, Article 125468. https://doi.org/10.1016/j.colsurfa.2020.125468

Uhd, J., Miotke, L., Ji, H. P., Dunaeva, M., Pruijn, G. J. M., Jørgensen, C. D., Kristoffersen, E. L., Birkedal, V., Yde, C. W., Nielsen, F. C., Hansen, J. & Astakhova, K. (2020). Ultra-fast detection and quantification of nucleic acids by amplification-free fluorescence assay. Analyst, 145(17), 5836-5844. https://doi.org/10.1039/d0an00676a

Kang, S., He, M., Chen, M., Wang, J., Zheng, L., Chang, X., Duan, H., Sun, D., Dong, M. & Cui, L. (2020). Ultrafast plasma immersion strategy for rational modulation of oxygen-containing and amino groups in graphitic carbon nitride. Carbon, 159, 51-64. https://doi.org/10.1016/j.carbon.2019.12.022

Liu, Y., He, M., Guo, R., Fang, Z., Kang, S., Ma, Z., Dong, M., Wang, W. & Cui, L. (2020). Ultrastable metal-free near-infrared-driven photocatalysts for H₂ production based on protonated 2D g-C₃N₄ sensitized with Chlorin e6. Applied Catalysis B: Environment and Energy, 260, Article 118137. https://doi.org/10.1016/j.apcatb.2019.118137

Rasmussen, H. Ø., Enghild, J. J., Otzen, D. E. & Pedersen, J. S. (2020). Unfolding and partial refolding of a cellulase from the SDS-denatured state: From β-sheet to α-helix and back. B B A - General Subjects, 1864(1), 129434 1-12. Article 129434. https://doi.org/10.1016/j.bbagen.2019.129434

Zelikin, A. N. (2020). Unique enzymatic repertoire reveals the tumour. Nature Chemistry, 12, 11-12. https://doi.org/10.1038/s41557-019-0400-0

Agergaard, T. E., Smith, M. & Nielsen, K. H. (2020). Vaccine Assemblages on Three HPV Vaccine-Critical Facebook Pages in Denmark from 2012 to 2019. Media and Communication, 8(2), 339-352. https://doi.org/10.17645/mac.v8i2.2858

Jiang, W., Zhang, X., Cheng, J., Song, J., Jin, Q., Wei, W., Dong, M. & Wang, X. (2020). Variation of fat globule size and fatty acids in human milk in the first 30 days of lactation. International Dairy Journal, 100, Article 104567. https://doi.org/10.1016/j.idairyj.2019.104567

Nielsen, K. H. (2020). Videnskabsbloggere til angreb. Weekendavisen, (Sektion 4 (Ideer)), 5.

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Kalinka Hansen