Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Barcena, T. G., Finster, K. & Yde, J. C. (2012). Gletscheres ekstreme økosystemer og deres respons på klimaændringer. Geologisk Nyt, 24-25.

Nilsson, L., Andersen, M., Balog, R., Lægsgaard, E., Hofmann, P., Besenbacher, F., Hammer, B., Stensgaard, I. & Hornekær, L. (2012). Graphene Coatings: Probing the Limits of the One Atom Thick Protection Layer. A C S Nano, 6(11), 10258–10266. https://doi.org/10.1021/nn3040588

Andersen, M., Hornekær, L. & Hammer, B. (2012). Graphene on metal surfaces and its hydrogen adsorption: A meta-GGA functional study. Physical Review B, 86(8), 085405. https://doi.org/10.1103/PhysRevB.86.085405

Temkiv, T. S., Finster, K., Dittmar, T., Hansen, B. M., Thyrhaug, R., Nielsen, N. W. & Karlson, U. G. (2012). Hailstones: a window into microbial life in storm clouds. Abstract from ISME Conference 2012, København, Denmark.

Temkiv, T. S., Finster, K., Dittmar, T., Hansen, B. M., Thyrhaug, R., Nielsen, N. W. & Gosewinkel, U. B. (2012). Hailstones: a window into microbial life in storm clouds. Poster session presented at ISME Conference 2012, København, Denmark.

Tarpgaard, I. H., Røy, H., Kjeldsen, K. U., Finster, K. & Jørgensen, B. B. (2012). High affinity sulfate reduction kinetics in marine sediment. Abstract from ISME Conference 2012, København, Denmark.

Ulstrup, S., Bianchi, M., Guan, D., Baraldi, A., Alfè, D., Hornekær, L. & Hofmann, P. (2012). High-temperature behavior of supported graphene: Electron-phonon coupling and substrate-induced doping. Physical Review B, 86. https://doi.org/10.1103/PhysRevB.86.161402

Cockell, C. S., Voytek, M. A., Gronstal, A. L., Finster, K., Kirshtein, J. D., Howard, K., Reitner, J., Gohn, G. S., Sanford, W. E., Horton, Jr., J. W., Kallmeyer, J., Kelly, L. & Powars, D. S. (2012). Impact disruption and recovery of the deep subsurface biosphere. Astrobiology, 12(3). https://doi.org/10.1089/ast.2011.0722

Scally, A., Dutheil, J. Y., Hillier, L. W., Jordan, G. E., Goodhead, I., Herrero, J., Hobolth, A., Lappalainen, T., Mailund, T., Marques-Bonet, T., McCarthy, S., Montgomery, S. H., Schwalie, P. C., Tang, Y. A., Ward, M. C., Xue, Y., Yngvadottir, B., Alkan, C., Andersen, L. N. ... Durbin, R. (2012). Insights into hominid evolution from the gorilla genome sequence. Nature, 483(7388), 169-75. https://doi.org/10.1038/nature10842

Zelikin, A. N. & Stadler, B. M. (2012). Intelligent Polymer Thin Films and Coatings for Drug Delivery. In H. M. Grandin & M. Textor (Eds.), Intelligent Surfaces in Biotechnology - Scientific and engineering concepts, enabling technologies, and translation to bio-oriented applications John Wiley & Sons Ltd.

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