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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Li, D., Sun, X., Gao, C. & Dong, M. (2020). Improved water flux and antifouling properties of cardo poly(aryl ether ketone) ultrafiltration membrane by novel sulfobetaine polyimides additive. Separation and Purification Technology, 251, Article 117144. https://doi.org/10.1016/j.seppur.2020.117144

Conzelmann, C., Müller, J. A., Perkhofer, L., Sparrer, K. M. J., Zelikin, A. N., Münch, J. & Kleger, A. (2020). Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Clinical Medicine, 20(6), e218-e221. https://doi.org/10.7861/clinmed.2020-0351

Eskandari, H., Ghanadian, M., Noleto-Dias, C., Lomax, C., Tawfike, A., Christiansen, G., Sutherland, D. S., Ward, J. L., Mohammad-Beigi, H. & Otzen, D. E. (2020). Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides. ACS Chemical Neuroscience, 11(19), 3161–3173. https://doi.org/10.1021/acschemneuro.0c00528

Strecker, C., Bärenfänger, M., Miehe, M., Spillner, E. & Meyer, B. (2020). In Silico Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to Synthesize an Inhibitor with Drug-Like Properties. ChemBioChem, 21(13), 1923-1931. https://doi.org/10.1002/cbic.201900289

Sun, D., Zhang, Y., Liu, Y., Wang, Z., Chen, X., Meng, Z., Kang, S., Zheng, Y., Cui, L., Chen, M., Dong, M. & Hu, B. (2020). In-situ homodispersely immobilization of Ag@AgCl on chloridized g-C₃N₄ nanosheets as an ultrastable plasmonic photocatalyst. Chemical Engineering Journal, 384, Article 123259. https://doi.org/10.1016/j.cej.2019.123259

Gao, Q., Zhang, J., Chen, C., Chen, M., Sun, P., Du, W., Zhang, S., Liu, Y., Zhang, R., Bai, M., Fan, C., Wu, J., Men, T. & Jiang, X. (2020). In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida albicans Infection. ACS Nano, 14(4), 3980-3990. https://doi.org/10.1021/acsnano.9b07896

Moller Sonderskov, S., Hyldgaard Klausen, L., Amland Skaanvik, S., Han, X. & Dong, M. (2020). In situ Surface Charge Density Visualization of Self-assembled DNA Nanostructures after Ion Exchange. ChemPhysChem, 21(13), 1474-1482. https://doi.org/10.1002/cphc.201901168

Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., PCAWG Drivers and Functional Interpretation Working Group, Reimand, J. & PCAWG Consortium (2020). Integrative pathway enrichment analysis of multivariate omics data. Nature Communications, 11(1), Article 735. https://doi.org/10.1038/s41467-019-13983-9

Mortensen, M. R., Skovsgaard, M. B., Märcher, A., Andersen, V. L., Palmfeldt, J., Nielsen, T. B., Tørring, T., Laursen, N. S., Andersen, K. R., Kjems, J. & Gothelf, K. V. (2020). Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. Bioconjugate Chemistry, 31(5), 1295-1300. https://doi.org/10.1021/acs.bioconjchem.0c00151

Jiang, A., Wang, Z., Li, Q. & Dong, M. (2020). Ionic Liquid-Assisted Synthesis of Hierarchical One-Dimensional MoP/NPC for High-Performance Supercapacitor and Electrocatalysis. ACS Sustainable Chemistry & Engineering, 8(16), 6343-6351. https://doi.org/10.1021/acssuschemeng.0c00238

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Kalinka Hansen