Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. & Nielsen, H. (2006). Formidling af naturvidenskab i presse, radio og tv. In H. Nielsen & K. H. Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie (Vol. 4, pp. 405-422). Aarhus Universitetsforlag.

Knudsen, H. & Nielsen, K. H. (2006). Forskning uden for universiteterne. In H. Nielsen & K. Hvidtfelt Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie, Bind 4 (Vol. 4, pp. 259-79). Aarhus Universitetsforlag.

Mailund, T., Schierup, M. H., Pedersen, C. N. S., Madsen, J. N., Hein, J. & Schauser, L. (2006). GeneRecon—A coalescent based tool for fine-scale association mapping. Bioinformatics, 22(18), 2317–2318.

Kragh, H., Lolck, M. L. & Nielsen, K. H. (2006). Geovidenskaberne i dansk kontekst. In H. Nielsen & K. H. Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie (Vol. 4, pp. 201-218). Aarhus Universitetsforlag.

Münster, J., Ziegelmüller, P., Spillner, E. & Bredehorst, R. (2006). High level expression of monomeric and dimeric human alpha1,3-fucosyltransferase V. Journal of Biotechnology, 121(4), 448-57. https://doi.org/10.1016/j.jbiotec.2005.08.015

Baouche, S., Gamborg, G., Petrunin, V. V., Luntz, A. C., Baurichter, A. & Hornekær, L. (2006). High translational energy release in H₂ (D₂) associative desorption from H (D) chemisorbed on C(0001). Journal of Chemical Physics, 125, 084712.

Mohey, R., Tolstrup, M., Jørgensen, L. B., Møller, B. K., Black, F. T., Kjems, J. & Obel, N. (2006). HIV-1 reverse Transcriptase Gene 103K/N and 184M/V Combinations in Tandem: Detection and Quantification of HIV-1 Populations in the CD45RO+ T-cell Compartment by a Double-ARMS Real-Time PCR assay. JAIDS: Journal of Acquired Immune Deficiency Syndromes , 41(2), 160-167. https://doi.org/10.1097/01.qai.0000191998.70034.64

Spillner, E., Kölln, J. & Bredehorst, R. (2006). Inactivation of complement by recombinant human C3 derivatives. In Current Topics in Complement (Vol. 586, pp. 347-60)

Nielsen, K. H. (2006). In search of the sea monster. Endeavour, 30(1), 36-40.

Sehgal, P., Sharma, M., Wimmer, R., Larsen, K. L. & Otzen, D. (2006). Interactions between anionic mixed micelles and α-cyclodextrin and their inclusion complexes: conductivity, NMR and fluorescence study. Colloid and Polymer Science, 284(8), 916-926. https://doi.org/10.1007/s00396-006-1466-y

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