Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Albrecht, M., Schaub, B., Gilles, S., Köhl, J., Altrichter, S., Voehringer, D., Spillner, E., Ehlers, M., Jönsson, F., Loser, K., Mayer, J. U., Rösner, L. M., Möbs, C., Heine, G. & Pfützner, W. (2022). Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology. European Journal of Immunology, 52(6), 851-855. https://doi.org/10.1002/eji.202270065

Nielsen, K. H. & Kragh, G. (2022). D4.1 First version of the Description of TIME4CS training programs. TIME4CS . https://doi.org/10.5281/zenodo.6906330

Mazo-Vargas, A., Langmüller, A. M., Wilder, A., van der Burg, K. R. L., Lewis, J. J., Messer, P. W., Zhang, L., Martin, A. & Reed, R. D. (2022). Deep cis-regulatory homology of the butterfly wing pattern ground plan. Science, 378(6617), 304-308. https://doi.org/10.1126/science.abi9407

Nielsen, K. H. (2022). Den forsvundne Indiana Jones. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2022). Den norske grødstrid. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2022). Det værst tænkelige. Weekendavisen, Sektion 4 (Ideer), 5.

Fjelstrup, S., Dupont, D. M., Bus, C., Enghild, J. J., Jensen, J. B., Birkenkamp-Demtröder, K., Dyrskjøt, L. & Kjems, J. (2022). Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer. NAR cancer, 4(3), Article zcac025. https://doi.org/10.1093/narcan/zcac025

Harms, M., Hansson, R. F., Carmali, S., Almeida-Hernández, Y., Sanchez-Garcia, E., Münch, J. & Zelikin, A. N. (2022). Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma Stability. Bioconjugate Chemistry, 33(4), 594-607. https://doi.org/10.1021/acs.bioconjchem.2c00034

Pérez-García, F., Brito, L. F., Irla, M., Jorge, J. M. P. & Sgobba, E. (2022). Editorial: Promising and sustainable microbial feedstocks for biotechnological processes. Frontiers in Microbiology, 13, Article 973723. https://doi.org/10.3389/fmicb.2022.973723

Irla, M. & Wendisch, V. F. (2022). Efficient cell factories for the production of N-methylated amino acids and for methanol-based amino acid production. Microbial Biotechnology, 15(8), 2145-2159. https://doi.org/10.1111/1751-7915.14067

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