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Recent research news on Artificial Biology

Single Protein-Mediated Vesicle Division

Steering group member of AUNAB, Prof. Brigitte Städler, has published a collaborative study in Advanced Materials on the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles.

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nayeri, Z., Aliakbari, F., Afzali, F., Parsafar, S., Gharib, E., Otzen, D. E. & Morshedi, D. (2022). Characterization of exogenous αSN response genes and their relation to Parkinson's disease using network analyses. Frontiers in Pharmacology, 13, Article 966760. https://doi.org/10.3389/fphar.2022.966760
Montasell, M. C., Monge, P., Carmali, S., Dias Loiola, L. M., Andersen, D. G., Løvschall, K. B., Søgaard, A. B., Kristensen, M. M., Pütz, J. M. & Zelikin, A. N. (2022). Chemical zymogens for the protein cysteinome. Nature Communications, 13(1), Article 4861. https://doi.org/10.1038/s41467-022-32609-1
Nielsen, K. H., Agergaard, T. E. & Kragh, G. (2022). Citizen Science in Denmark: A national survey across research fields, institutions, and projects. Poster session presented at Engaging Citizen Science, Aarhus, Denmark.
Nielsen, K. H., Kragh, G. & Agergaard, T. E. (2022). Citizen science in Denmark at a critical stage: a national survey across research fields, institutions, and projects. P o S - Proceedings of Science, 418, Article 058. https://pos.sissa.it/418/058/pdf
Pourjafar, M., Miehe, M., Najafi, R., Soleimani, M. & Spillner, E. (2022). Construction, expression and functional characterization of an engineered antibody against tumor antigen MUC-1C. Protein Expression and Purification, 199, Article 106148. https://doi.org/10.1016/j.pep.2022.106148
Oh, S., Tabassian, R., Thangasamy, P., Mahato, M., Hiep Nguyen, V., Nam, S., Huapeng, Z. & Oh, I.-K. (2022). Cooling-Accelerated Nanowire-Nitinol Hybrid Muscle for Versatile Prosthetic Hand and Biomimetic Retractable Claw. Advanced Materials, 32(18), Article 2111145. https://doi.org/10.1002/adfm.202111145
Amin, H., Šantl-Temkiv, T., Cramer, C., Vestergaard, D. V., Holst, G. J., Elholm, G., Finster, K., Bertelsen, R. J., Schlünssen, V., Sigsgaard, T. & Marshall, I. P. G. (2022). Cow Farmers' Homes Host More Diverse Airborne Bacterial Communities Than Pig Farmers' Homes and Suburban Homes. Frontiers in Microbiology, 13, Article 883991. https://doi.org/10.3389/fmicb.2022.883991
Neumann, C., Rosenbaek, L. L., Flygaard, R. K., Habeck, M., Karlsen, J. L., Wang, Y., Lindorff-Larsen, K., Gad, H. H., Hartmann, R., Lyons, J. A., Fenton, R. A. & Nissen, P. (2022). Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity. EMBO Journal, 41(23), Article e110169. https://doi.org/10.15252/embj.2021110169
Albrecht, M., Schaub, B., Gilles, S., Köhl, J., Altrichter, S., Voehringer, D., Spillner, E., Ehlers, M., Jönsson, F., Loser, K., Mayer, J. U., Rösner, L. M., Möbs, C., Heine, G. & Pfützner, W. (2022). Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology. European Journal of Immunology, 52(6), 851-855. https://doi.org/10.1002/eji.202270065
Nielsen, K. H. & Kragh, G. (2022). D4.1 First version of the Description of TIME4CS training programs. TIME4CS . https://doi.org/10.5281/zenodo.6906330

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Kalinka Hansen