Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Yang, S., Youn, W., Rheem, H. B., Han, S. Y., Kim, N., Han, S., Schattling, P., Städler, B. & Choi, I. S. (2025). Construction of Liposome-Based Extracellular Artificial Organelles on Individual Living Cells. Angewandte Chemie - International Edition, 64(3), Article e202415823. https://doi.org/10.1002/anie.202415823

Nguyen, M. T. A., Andersen, E. S. & Pothoulakis, G. (2025). Construction of Small Genes with Repetitive Elements Using Oligo Extension and Golden Gate Assembly. In D. Schindler (Ed.), Golden Gate Cloning (pp. 219-227). Humana Press. https://doi.org/10.1007/978-1-0716-4220-7_12

Nielsen, K. H. & Andersen, C. (2025). Contested Narratives: The Dual-Use Dilemma in Atomic and Quantum Technologies. Poster session presented at PCST 2025 Using Science Communication to effect positive change, Aberdeen, United Kingdom.

Gadeberg, T. A. F., Jørgensen, M. H., Olesen, H. G., Lorentzen, J., Harwood, S. L., Almeida, A. V., Fruergaard, M. U., Jensen, R. K., Kanis, P., Pedersen, H., Tranchant, E., Petersen, S. V., Thøgersen, I. B., Kragelund, B. B., Lyons, J. A., Enghild, J. J. & Andersen, G. R. (2025). Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring. Nature Structural and Molecular Biology, 32(5), 884-895. Article 872536. https://doi.org/10.1038/s41594-024-01467-4

Jensen, R. K., Miehe, M., Gandini, R., Jørgensen, M. H., Spillner, E. & Andersen, G. R. (2025). Cryo-EM Structure of FcεRI Bound IgE Reveals Multiple Defined Conformations of the Fab-Fc Hinge. Allergy: European Journal of Allergy and Clinical Immunology. Advance online publication. https://doi.org/10.1111/all.70132

Li, B., Xu, M., Zhang, D., Zhang, Y., Li, Q. & Dong, M. (2025). Current-carrying friction of atomically thin molybdenum disulfide. Applied Surface Science, 685, Article 162021. https://doi.org/10.1016/j.apsusc.2024.162021

Nielsen, K. H. (2025). DEI-fri forskning. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2025). Den lange kamp om lymfekarrene. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2025). Den moralske fare ved gratis lægehjælp. Weekendavisen, Sektion 4 (Ideer), 5.

Tang, Y., Friec, A. L., Chen, M. & Sun, D. (2025). Designed Biomaterial-Enhanced Cell Transplantation for Neural Tissue Engineering. Aggregate, 6(5), Article e70022. https://doi.org/10.1002/agt2.70022

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