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Recent research news on Artificial Biology

Single Protein-Mediated Vesicle Division

Steering group member of AUNAB, Prof. Brigitte Städler, has published a collaborative study in Advanced Materials on the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles.

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Mishra, A., Zubia-Aranburu, J., Zuzic, L., Saeed, K., Nielsen, J., Schio̷tt, B., Dong, M., Otzen, D. E. & Weidner, T. (2026). Structure of α-Synuclein Bound to Polystyrene Surfaces Probed by Experimental and Theoretical Sum Frequency Generation Spectroscopy. Langmuir : the ACS journal of surfaces and colloids, 42(11), 7653-7659. https://doi.org/10.1021/acs.langmuir.5c05658
Vinther, S. C., Resag, A., Le, K. T. T., Zelle-Rieser, C. C., Strandt, H., Malle, M. G., Christiansen, S. H., Del Frari, B., Stigger, T., Schilling, B., Wohlfarth, J., Thiel, S., Valero, J., Stoitzner, P. & Kjems, J. (2026). Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform. Journal of Controlled Release, 392, 114741. Article 114741. https://doi.org/10.1016/j.jconrel.2026.114741
Cerda-Jara, C. A., Scoyni, F., Zolotarov, G., Bhaskar, P., León-Periñán, D., Kjems, J. & Rajewsky, N. (2026). The history and function of a circular RNA. Nature Communications, 17(1), Article 3862. https://doi.org/10.1038/s41467-026-71822-0
Otzen, D. E., Minero, G. A. S., Røder, H. L., Torp, A. M., Herschend, J., Nielsen, L. G., Moshynets, O., Nielsen, J., Meyer, R. L., Dueholm, M. K. D. & Burmølle, M. (2026). The house that Kocuria built: A potential role for functional amyloid in the unique cube-based structure of K. varians biofilms. Microbe (Netherlands), 10, Article 100676. https://doi.org/10.1016/j.microb.2026.100676
Peña-Díaz, S., Jiang, Y., Zhang, Z., Daugberg, A., Ferreira, P., López Hernández, M., Mittal, C., Ramos, M. J., Pedersen, J. S., Dueholm, M. K. D., Qin, C., Wang, H. & Otzen, D. E. (2026). The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid. Advanced Science, 13(4), Article e17090. https://doi.org/10.1002/advs.202517090
Zhang, Y., Pilati, D., Dong, M. & Howard, K. A. (2026). The interaction of PD-1/PD-L1 and its inhibition by anti-PD-L1 antibody at the single-molecule level. FEBS Letters, 600(8), 1237-1247. https://doi.org/10.1002/1873-3468.70245
The Microflora Danica Consortium (2026). The Microflora Danica atlas of Danish environmental microbiomes. Nature, 649(8098), 971-981. https://doi.org/10.1101/2024.06.27.600767, https://doi.org/10.1038/s41586-025-09794-2
De Dios Andres, P., Garg, A., Alam, R., Westensee, I. N., Kjaergaard, M. & Städler, B. (2026). Transmembrane Condensation in Albumin-Loaded Giant Vesicles Induced by an Intrinsically Disordered Protein. ChemSystemsChem, 8(3), Article e00076. https://doi.org/10.1002/syst.202500076
Nielsen, K. H. (2026). Tvivlsom åbenhed. Weekendavisen, Sektion 4 (Ideer), 5.
Nielsen, K. H. (2026). Vidensblokkere. Weekendavisen, Sektion 4 (Ideer), 5.

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Revised 03.03.2026
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Kalinka Hansen