Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. & Nielsen, H. (2006). Kulturel natur. Weekendavisen, 13.

Nielsen, K. H. & Ries, C. J. (2006). Kvinder i naturvidenskaberne. In H. Nielsen & K. H. Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie (Vol. 4, pp. 347-364). Aarhus Universitetsforlag.

Nielsen, K. H. & Serritzlew, C. (2006). Making Things Public. Danske Museer, 19(1), 13-5.

Nielsen, K. H. & Serritzlew, C. (2006). Markante kvinder i dansk naturvidenskab. Forum for Koen og Kultur.

Morth, J. P., Sørensen, T. L.-M. & Nissen, P. (2006). Membrane's Eleven: heavy-atom derivatives of membrane-protein crystals. Acta Crystallographica. Section D: Biological Crystallography, D62(8), 877-882.

Hornekær, L., Sljivancanin, Z., Xu, W., Otero, R., Rauls, E., Stensgaard, I., Lægsgaard, E., Hammer, B. & Besenbacher, F. (2006). Metastable Structures and Recombination Pathways for Atomic Hydrogen on the Graphite (0001) Surface. Physical Review Letters, 96, 156104.

Jensen, A.-M. L., Sørensen, T. L.-M., Olesen, C., Møller, J. V. & Nissen, P. (2006). Modulatory and catalytic modes of ATP binding by the calcium pump. EMBO Journal, 25(11), 2305-2314.

Grunwald, T., Bockisch, B., Spillner, E., Bredehorst, R., Ring, J. & Ollert, M. W. (2006). Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3). Journal of Allergy and Clinical Immunology, 117(4), 848-854. https://doi.org/10.1016/j.jaci.2005.12.1331

Pedersen, J. S., Dikov, D. & Otzen, D. (2006). N- and C-Terminal Hydrophobic Patches Are Involved in Fibrillation of Glucagon. Biochemistry, 45(48), 14503-14512. https://doi.org/10.1021/bi061228n

Ebbesen, M. & Andersen, S. (2006). Nanoethics: General Principles and Christian Discourse. Journal of Lutheran Ethics , (2).

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