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Recent research news on Artificial Biology

Single Protein-Mediated Vesicle Division

Steering group member of AUNAB, Prof. Brigitte Städler, has published a collaborative study in Advanced Materials on the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles.

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Pedersen, A. B., Andersen, D. G., Jakobsen, J. H., Montasell, M. C. & Zelikin, A. N. (2025). Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells. Bioconjugate Chemistry, 36(4), 782-791. https://doi.org/10.1021/acs.bioconjchem.5c00043
Skovborg, G., Svejsø, F. H., Müller, C., Jensen, B. N., Jensen, J. G., Majidi, S. E., Matthiesen, C. L. & Chen, M. (2025). Replication of patient specific circulating tumor cells on a microfibrous filter for drug screening. Nanoscale, 17(18), 11592-11604. https://doi.org/10.1039/d4nr05294c
Golan, N., Parizat, A., Tabachnikov, O., Barnea, E., Olsen, W. P., Otzen, D. E. & Landau, M. (2025). Resilience and Charge-Dependent Fibrillation of functional amyloid: Interactions of Pseudomonas Biofilm-Associated FapB and FapC Amyloids. The Journal of Biological Chemistry, 301(2), Article 108096. https://doi.org/10.1016/j.jbc.2024.108096
Jiang, Y. & Kjems, J. (2025). RNA denaturation underlies circular RNA separation. Nucleic Acids Research, 53(21), Article gkaf1160. https://doi.org/10.1093/nar/gkaf1160
Nowak, J. S., Olesen, S., Tian, P., Bærentsen, R. L., Brodersen, D. E. & Otzen, D. E. (2025). Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase. Biochimica et Biophysica Acta - Proteins and Proteomics, 1873(4), Article 141072. https://doi.org/10.1016/j.bbapap.2025.141072
Kristoffersen, E. L., McRae, E. K. S., Sørensen, N. R., Holliger, P. & Andersen, E. S. (2025). Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis. Nucleic Acids Research, 53(11), Article gkaf057. https://doi.org/10.1093/nar/gkaf057
Fage-Butler, A., Ledderer, L. & Nielsen, K. H. (Eds.) (2025). Science communication and trust. Palgrave Macmillan. https://doi.org/10.1007/978-981-96-1289-5
Stenberg, K., Korhonen, S., Seemab, U., Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025). Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX. European Journal of Pharmaceutical Sciences, 212, Article 107217. https://doi.org/10.1016/j.ejps.2025.107217
Xia, D., Shi, T., Cao, W., Li, B., Wang, D., Liang, C. & Dong, M. (2025). Self-healing hydrogel based on polyvinyl alcohol/dextran with hyperglycemia-triggered cascade enzyme catalytic activity promotes diabetic wound healing. Journal of Colloid and Interface Science, 693, Article 137615. https://doi.org/10.1016/j.jcis.2025.137615
Holleufer, S. F., Hopkinson, A. T., Sutherland, D. S., Li, Z., Lauritsen, J. V., Hornekær, L. & Cassidy, A. (2025). Silicon oxide nanoparticles grown on graphite by co-deposition of the atomic constituents. Physical Chemistry Chemical Physics, 27(26), 13906-13916. https://doi.org/10.1039/d5cp01089f

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Kalinka Hansen