Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Laursen, S. H., Hansen, S. G., Taskin, M. B., Chen, M., Wogensen, L., Nygaard, J. V. & Axelsen, S. M. (2023). Electrospun nanofiber mesh with connective tissue growth factor and mesenchymal stem cells for pelvic floor repair: Long-term study. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 111(2), 392-401. https://doi.org/10.1002/jbm.b.35158

Roeters, S. J., Strunge, K., Pedersen, K. B., Golbek, T. W., Bregnhøj, M., Zhang, Y., Wang, Y., Dong, M., Nielsen, J., Otzen, D. E., Schiøtt, B. & Weidner, T. (2023). Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces. Nature Communications, 14(1), Article 5731. https://doi.org/10.1038/s41467-023-39843-1

Ye, Z., Tan, C., Huang, X., Ouyang, Y., Yang, L., Wang, Z. & Dong, M. (2023). Emerging MoS₂ Wafer-Scale Technique for Integrated Circuits. Nano-Micro Letters, 15(1), Article 38. https://doi.org/10.1007/s40820-022-01010-4

Nielsen, K. H. (2023). En pandemi af tilbagetrækninger. Weekendavisen, Sektion 4 (Ideer), 5.

Eriksen, J., Ebbesen, M., KT, E., Hjermitslev, C., Knudsen, C., Bertelsen, P., Nøhr, C. & Weber, D. (2023). Equity in digital healthcare – the case of Denmark. Frontiers in Public Health, 11, 1-6. Article 1225222. https://doi.org/10.3389/fpubh.2023.1225222

Rheinbay, E., Nielsen, M. M., Abascal, F., Wala, J. A., Shapira, O., Tiao, G., Hornshøj, H., Hess, J. M., Juul, R. I., Lin, Z., Feuerbach, L., Sabarinathan, R., Madsen, T., Kim, J., Mularoni, L., Shuai, S., Lanzós, A., Herrmann, C., Maruvka, Y. E. ... PCAWG Drivers and Functional Interpretation Working Group (2023). Erratum: Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (Nature (2020) 578 7793 (102-111)). Nature, 614(7948), E40. https://doi.org/10.1038/s41586-022-05599-9

Aagaard, J. B., Fischer, M., Lober, J., Bolbro Neumann, F., Allahverdi, D., Sivelle, C., Miehe, M. & Spillner, E. (2023). Extract-shaped immune repertoires as source for nanobody-based human IgE in grass pollen allergy. Molecular Biotechnology, 65(9), 1518-1527. https://doi.org/10.1007/s12033-023-00664-8

Nielsen, K. H. (2023). Fagfællebedømt racisme. Weekendavisen, Sektion 4 (Ideer), 5.

Rasmussen, H. Ø., Kumar, A., Shin, B., Stylianou, F., Sewell, L., Xu, Y., Otzen, D. E., Pedersen, J. S. & Matthews, S. J. (2023). FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC. Journal of Molecular Biology, 435(2), Article 167878. https://doi.org/10.1016/j.jmb.2022.167878

Nielsen, K. H. (2023). Fladjordsteori for sociologer. Weekendavisen, Sektion 4 (Ideer), 5.

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