Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H., Kjaer, C. R. & Dahlgaard, J. (2008). Scientists' understanding of public communication of science and technology. Abstract from PCST-10 Bridges to the future, Malmø, Sweden.

Andersen, E. S., Nielsen, M. M., Dong, M., Besenbacher, F., Kjems, J. & Gothelf, K. V. (2008). Software package for the design and analysis of DNA origami structures. Paper presented at FNANO 2008, Snowbird, United States.

Otero Martin, R., Xu, W., Lukas, M., Kelly, R. E. A., Laegsgaard, E., Stensgaard, I., Kjems, J., Kantorovich, L. N. & Besenbacher, F. (2008). Specificity of Watson-Crick Base Pairing on a Solid Surface Studied at the Atomic Scale. Angewandte Chemie, 47(50), 9673-9676. https://doi.org/10.1002/anie.200803333

Christensen, P. A., Pedersen, J. S., Christiansen, G. & Otzen, D. (2008). Spectroscopic Evidence for the Existence of an Obligate Pre-Fibrillar Oligonomer during Glucagon Fibrillation. FEBS Letters, (582), 1341-1345.

Andersen, L. N. & Mandjes, M. (2008). Structural properties of reflected Lévy processes. (pp. 1-22). Thiele Centre, Institut for Matematiske Fag, Aarhus Universitet.

Odadzic, D., Bramsen, J. B., Smicius, R., Bus, C., Kjems, J. & Engels, J. W. (2008). Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference. Bioorganic & Medicinal Chemistry, 16(1), 518-529. https://doi.org/10.1016/j.bmc.2007.09.019

Knudsen, H., Nielsen, H. & Nielsen, K. H. (2008). The Carlsberg Laboratory: envisioning utility-oriented basic research. In H. Kragh, P. C. Kjærgaard, H. Nielsen & K. Hvidtfelt Nielsen (Eds.), Science in Denmark: A Thousand-Year History (1 ed., pp. 487-493). Aarhus Universitetsforlag.

Knudsen, H., Nielsen, H. & Nielsen, K. H. (2008). The Danish insulin adventure: two academics as entrepreneurs. In H. Kragh, P. C. Kjærgaard, H. Nielsen & K. Hvidtfelt Nielsen (Eds.), Science in Denmark: A Thousand-Year History (1 ed., pp. 493-496). Aarhus Universitetsforlag.

Nielsen, K. H. (2008). The making of a national science event: The Festival of Research in Denmark. In C. Michelsen (Ed.), Proceedings of the Fourth Nordic Network of Researchers in Science Communication Symposium (Vol. 3, pp. 34-46). Center for Science and Mathematics Education, University of Southern Denmark.

Ebbesen, M. & Pedersen, B. D. (2008). The principle of respect for autonomy--concordant with the experience of oncology physicians and molecular biologists in their daily work? BMC Medical Ethics, 9, 5. https://doi.org/10.1186/1472-6939-9-5

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