Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

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Sanchez-Weatherby, J., Sandy, J., Mikolajek, H., Lobley, C. M. C., Mazzorana, M., Kelly, J., Preece, G., Littlewood, R. & Sørensen, T. L. M. (2019). VMXi: a fully automated, fully remote, high-flux in situ macromolecular crystallography beamline. Journal of Synchrotron Radiation, 26(Part 1), 291-301. https://doi.org/10.1107/S1600577518015114

Nielsen, K. H. (2019). Vores gener. Vi er næsten ens - og så alligevel unikke. Avisen Danmark, 12.

Su, C., Yin, Z., Yan, Q. B., Wang, Z., Lin, H., Sun, L., Xu, W., Yamada, T., Ji, X., Zettsu, N., Teshima, K., Warner, J. H., Dincă, M., Hu, J., Dong, M., Su, G., Kong, J. & Li, J. (2019). Waterproof molecular monolayers stabilize 2D materials. Proceedings of the National Academy of Sciences (PNAS), 116(42), 20844-20849. https://doi.org/10.1073/pnas.1909500116

Bak, E. N., Larsen, M. G., Jensen, S. K., Nornberg, P., Moeller, R. & Finster, K. (2019). Wind-Driven Saltation: An Overlooked Challenge for Life on Mars. Astrobiology, 19(4), 497-505. https://doi.org/10.1089/ast.2018.1856

Schmid, J. M., Skjold, T., Kolstad, H. A., Miehe, M., Spillner, E. & Hoffmann, H. J. (2019). Work-related allergic asthma: Clinical work-up of a 45-year old male working in animal feed producing industry. Allergy: European Journal of Allergy and Clinical Immunology, 74, 316-316.

Feng, L., Chen, M., Qian, Y., Tian, J., Liu, J., Niu, S., Muhammad, H., Dong, M. & Zhong, J. (2019). Wrinkles with changing orientation and complexity in a single piece of thin film. Journal of Applied Physics, 125(24), Article 245301. https://doi.org/10.1063/1.5037058

Kuziemski, M., Frahm, N. & Schiølin, K. (2019). Zuckerberg and Warren want to fix Big Tech in different ways—and neither of them will work. Quartz. https://qz.com/1601587/elizabeth-warren-and-mark-zuckerbergs-differing-views-on-big-tech/amp/

Alam, P., Bousset, L., Melki, R. & Otzen, D. E. (2019). α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities. Journal of Neurochemistry, 150(5), 522-534. https://doi.org/10.1111/jnc.14808

Nielsen, K. H. (2018). #. Weekendavisen, Sektion 4 (Ideer), 10.

Valero Moreno, J., Pal, N., Dhakal, S., Walter, N. G. & Famulok, M. (2018). A bio-hybrid DNA rotor–stator nanoengine that moves along predefined tracks. Nature Nanotechnology, 13(6), 496-503. https://doi.org/10.1038/s41565-018-0109-z

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