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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, E. J. B., Nielsen, J. M., Becker, D., Karlas, A., Prakash, H., Glud, S. Z., Merrison, J., Besenbacher, F., Meyer, T. F., Kjems, J. & Howard, K. A. (2010). Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles. Pharmaceutical Research, 27(12), 2520-7. https://doi.org/10.1007/s11095-010-0255-y

Seismann, H., Blank, S., Cifuentes, L., Braren, I., Bredehorst, R., Grunwald, T., Ollert, M. & Spillner, E. (2010). Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity. Clinical and Molecular Allergy, 8. https://doi.org/10.1186/1476-7961-8-7

Hansen, T. B., Bramsen, J. B. & Kjems, J. (2010). Re-inspection of small RNA sequence datasets reveals several novel human miRNA genes. PLoS One, 5(6), e10961. https://doi.org/10.1371/journal.pone.0010961

Basse-O'Connor, A. (2010). Representation of Gaussian semimartingales with applications to the covariance function. Stochastics: An International Journal of Probability and Stochastic Processes , 82(4), 381-401. https://doi.org/10.1080/17442500903251857

Tørring, T., Toftegaard, R., Arnbjerg, J., Ogilby, P. R. & Gothelf, K. V. (2010). Reversible pH-Regulated Control of Photosensitized Singlet Oxygen Production Using a DNA i-Motif. Angewandte Chemie International Edition, 49, 7923-7925.

Madsen, J. B., Dupont, D. M., Andersen, T. B., Nielsen, A. F., Sang, L., Brix, D. M., Jensen, J. K., Broos, T., Hendrickx, M. L. V., Christensen, A., Kjems, J. & Andreasen, P. A. (2010). RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1. Biochemistry, 49(19), 4103-15. https://doi.org/10.1021/bi100066j

Xue, Q., Chen, H., Li, Q., Yan, K., Besenbacher, F. & Dong, M. (2010). Room-temperature high-sensitivity detection of ammonia gas using the capacitance of carbon/silicon heterojunctions. Energy & Environmental Science, 3, 288-291.

Nielsen, K. H. (2010). Rudkøbing Apotek: To store mænds barndomshjem. In 1001 fortællinger om Danmark Kulturarvsstyrelsen. http://www.kulturarv.dk/1001fortaellinger/da_DK/rudkoebing-apotek/main

Nielsen, K. H. (2010). Science as Art Competition. In D. H. Guston (Ed.), Encyclopedia of Nanotechnology and Society (pp. 698-699). SAGE Publications.

Nielsen, K. H. (2010). Science Cafés. In D. H. Guston (Ed.), Encyclopedia of Nanotechnology and Society (pp. 699-700). SAGE Publications.

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Kalinka Hansen