Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

Sort by: Date | Author | Title

Finster, K. & Rullkötter, J. (Ed.) (2003). The activity of sulphate reducers in the rhizosphere of marine macrophytes. Paper presented at BioGeoChemistry of Tidal Flats. Proceedings of a Workshop, Hanse Institute of Advance Study, Delmenhorts 14-17 May, 2003.

Andersen, F. F., Tange, T. Ø., Sinnathamby, T., Lohmann, J. S., Andersen, K. E., Kjems, J., Westergaard, O. & Knudsen, B. R. (2003). The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation. Poster session presented at Mechanisms of Eukaryotic Transcription, Cold Spring Harbor, United States.

Sand-Jensen, K., Kjaer, C. R., Dahlgaard, J. & Andersen, E. S. (2003). Ud af osteklokken. Aktuel Naturvidenskab, (4), 28-29.

Lindtner, S., Felber, B. K. & Kjems, J. (2002). An element in the 3′untranslated region of human LINE-1 retrotransposon mRNA binds NXT1 (TAP) and can function as a nuclear export element. RNA, 8, 345-356.

Hobolth, A. & Jensen, E. B. V. (2002). A note on design-based versus model-based variance estimation in stereology. Advances in Applied Probability, 34, 484-490. https://doi.org/10.1239/aap/1033662161

Daelemans, D., Afonina, E., Nilsson, J., Werner, G., Kjems, J., Clercq, E., Pavlakis, G. N. & Vandamme, A. (2002). A novel inhibitor of the CRM-1 mediated pathway. Proceedings of the National Academy of Sciences (PNAS), 99, 14440-14445.

Hansen, A., Nørberg, P., Merrison, J., Lomstein, B. A. & Finster, K. (2002). A simulation facility for biological experiments. Paper presented at Graz, Austria, 16-19 September (ESA SP-518, November 2002).

Pedersen, C. N. S. (2002). Bioinformatik ved Aarhus Universitet. Biozoom, (3), 12-18.

Pedersen, C. N. S., Scharling, T., Guigó, R. (Ed.) & Gusfield, D. (Ed.) (2002). Comparative Methods for Gene Structure Prediction in Homologous Sequences. In Ikke angivet (2452 of Lecture Notes in Computer Science ed., Vol. 2452/2002, pp. 220-234). Springer.

Lund, M. & Kjems, J. (2002). Defining a 5′ splice site by functional selection in the presence and absence of U1 snRNA 5′-end. RNA, 8, 166-179.

Displaying results 3361 to 3370 out of 3470

337