Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Kristensen, T. G., Pedersen, C. S., Thomsen, R. & Christensen, M. H. (2009). Largest Common Chemical Feature Subtree as a Virtual Screening Method. Poster session presented at 17th Annual International Conference on Intelligent Systems for Molecular Bioligy (ISMB) & 8th European Conference on Computational Biology (ECCB), Stockholm, Sweden. http://www.iscb.org/ismbeccb2009/poster_list.php?cat=C

Nevo, I., Kapishnikov, S., Birman, A., Dong, M., Cohen, S. R., Kjaer, K., Besenbacher, F., Stapelfeldt, H., Seideman, T. & Leiserowitz, L. (2009). Laser-induced aligned self-assembly on water surfaces. Journal of Chemical Physics, 130(14), 144704. https://doi.org/10.1063/1.3108540

Basse-O'Connor, A. & Pedersen, J. (2009). Lévy driven moving averages and semimartingales. Stochastic Processes and Their Applications, 119(9), 2970-2991. https://doi.org/10.1016/j.spa.2009.03.007

Andersen, L. N. & Asmussen, S. (2009). Local time asymptotics for centered Lévy processes with two-sided reflection. Thiele Centre, Institut for Matematiske Fag, Aarhus Universitet.

Andersen, L. N. (2009). Loss Rates and Structural Properties of Reflected Stochastic Processes. Aarhus Universitetsforlag.

Dong, M. (Ed.) (2009). Materials Special Issue: Nanomaterials. In Mangler titel

Birkedal, V., Krüger, A. C., Nochyporuk-Zloy, V., Kjems, J. & Besenbacher, F. (2009). Methods for single molecule FRET microsocpy data analysis. Poster session presented at 15^th Anniversary International Workshop on "Single Molecule Spectroscopy and Ultra Sensitive Analysis in the Life Sciences", Berlin, Germany.

Cockell, C. S., Gronstal, A. L., Voytek, M. A., Kirshtein, J. D., Finster, K., Sanford, W. E., Glamoclija, M., Grohn, G. S., Powers, D. S. & Horton Jr., J. W. (2009). Microbial abundance in the deep subsurface of the Chesapeake Bay impact crater: Relationship to lithology and impact processes. Geological Society of America. Special Papers, 458, 941-950.

Bunge, M., Søbjerg, L. S., Lindhardt, A., Gauthier, D., Hyldgaard, M., Hause, G., Finster, K., Skrydstrup, T. & Meyer, R. L. (2009). Microbial formation of palladium nanocatalysts. Poster session presented at Microbial formation of palladium nanocatalysts, Göteborg, Sweden.

Nørnberg, P., Vendelboe, A. L., Gunnlaugsson, H. P., Merrison, J. P., Finster, K. & Jensen, S. K. (2009). Mineralogy after an experimental forest fire on Quaternary soil goethite/ferrihydrite, compared with a hematite, maghemite, goethite containing topsoil. Clay Minerals, 44, 239-247.

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