Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Wu, X., Xia, D., Shi, T., Li, B., Wang, D., Liang, C. & Dong, M. (2025). Thermo-responsive microneedles patch for transdermal drug delivery via squeezing in diabetic foot ulcers. Journal of Materials Science and Technology, 205, 299-314. https://doi.org/10.1016/j.jmst.2024.03.068

O’Leary, E., Jiang, Y., Kristensen, L. S., Hansen, T. B. & Kjems, J. (2025). The therapeutic potential of circular RNAs. Nature Reviews Genetics, 26(4), 230-244. Article 2629. https://doi.org/10.1038/s41576-024-00806-x

Brito, L. F., Friis, M. K., Zhu, H., Brautaset, T., Wendisch, V. F. & Irla, M. K. (2025). Tools and Strategies for Engineering Bacillus methanolicus: A Versatile Thermophilic Platform for Sustainable Bioproduction from Methanol and Alternative Feedstocks. Synthetic Biology and Engineering, 3(4). https://doi.org/10.70322/sbe.2025.10016

Paiva, P., Teixeira, L. M. C., Ferreira, P., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Transforming Computational Power into Environmental Solutions: HPC-driven Research on Urethanase-mediated Plastic Degradation. Procedia Computer Science, 267, 207-217. https://doi.org/10.1016/j.procs.2025.08.247

Andersen, D. G., Pedersen, A. B., Montasell, M. C., Moesgaard, S., Bohn, A. B. & Zelikin, A. N. (2025). Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes. Advanced Functional Materials, 35(34), Article 2503381. https://doi.org/10.1002/adfm.202503381

Bregnhøj, M., Wili, N., Nielsen, A. B., Jensen, S. J. K., Nørnberg, P., Nielsen, N. C., Skibsted, J. & Finster, K. (2025). Triboelectrically Mediated Surface Reduction of Quartz Sand by Tumbling in Hydrogen Gas. Journal of Physical Chemistry C, 129(24), 10900-10910. https://doi.org/10.1021/acs.jpcc.5c02082

Nielsen, K. H. (2025). Trump og atomet. Weekendavisen, Sektion 4 (Ideer), 5.

Li, T. H., Ma, L., Wang, L., Wang, H. B., Li, B., Han, M. Y., Li, D. F., Bai, C. G., Dong, M. D., Shen, L. H., Ma, S. & Qi, F. (2025). Ultra-wide band electromagnetic wave absorption by decorating the magnetic particles on two-dimensional Ti₃C₂T_x. Rare Metals, 44(3), 1844-1855. Article 204105. https://doi.org/10.1007/s12598-024-03170-1

Chang, Y., Cheng, Y., Jia, R., Wang, R., Xu, Q., Gong, L., Wei, Y., Tang, B., Guo, C., Sun, B., He, X., Li, X., Gong, L., Ye, H., Wang, X., Dai, Y., Dong, M., Tang, Y., Zhang, F. ... Pan, T. (2025). Unified iontronic sensing for operando monitoring of physical-chemical events in lithium-ion batteries. National Science Review, 12(6), Article nwaf151. https://doi.org/10.1093/nsr/nwaf151

Paiva, P., Teixeira, L. M. C., Wei, R., Liu, W., Weber, G., Morth, J. P., Westh, P., Petersen, A. R., Johansen, M. B., Sommerfeldt, A., Sandahl, A., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Unveiling the enzymatic pathway of UMG-SP2 urethanase: insights into polyurethane degradation at the atomic level. Chemical Science, 16(5), 2437-2452. https://doi.org/10.1039/d4sc06688j

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