Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. (2010). Forskning, innovation og uddannelse i Japan. Videnskab.dk. http://videnskab.dk/content/dk/blogs/bag_om_videnskaben/forskning_innovation_og_uddannelse_i_japan

Nielsen, K. H. & Schneider, J. W. (2010). Forskning: Kvalitet kommer ikke af statistik. Politiken, (Kultur), 8. http://politiken.dk/debat/analyse/ECE1069280/kvalitet-kommer-ikke-af-statistik-/

Nielsen, K. H. (2010). Framing. In D. H. Guston (Ed.), Encyclopedia of Nanotechnology and Society (pp. 256-257). SAGE Publications.

Jepsen, M. DE., Nechyponuk-Zloy, V., Beerens, N., Besenbacher, F., Kjems, J. & Birkedal, V. (2010). FRET-studies of the HIV-1 genome upon tRNA annealing.

Dueholm, M. S., Petersen, S. V., Sønderkær, M., Larsen, P., Christiansen, G., Hein, K. L., Enghild, J. J., Nielsen, J. L., Nielsen, K. L., Nielsen, P. H. & Otzen, D. E. (2010). Functional amyloid in Pseudomonas. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2010.07269.x

Otzen, D. (2010). Functional amyloid: turning swords into plowshares. Prion, 4(4), 256-64.

Otzen, D. (2010). Functional bacterial amyloids in biofilms. Annual Biofilm Highlights.

Andersen, C. B., Hicks, M. R., Vetri, V., Vandahl, B., Rahbek-Nielsen, H., Thøgersen, H., Thøgersen, I., Enghild, J. J., Serpell, L. C., Rischel, C. & Otzen, D. E. (2010). Glucagon fibril polymorphism reflects differences in protofilament backbone structure. Journal of Molecular Biology, 397(4), 932-46. https://doi.org/10.1016/j.jmb.2010.02.012

Nielsen, K. H. (2010). Her går det godt: - og send så flere penge! Videnskab.dk. http://videnskab.dk/content/dk/blogs/bag_om_videnskaben/her_gar_det_godt_%E2%80%93_og_send_sa_flere_penge

Sand, A., Brask, A. T., Pedersen, C. N. S., Mailund, T. & Brask, A. T. (2010). HMMlib: A C++ Library for General Hidden Markov Models Exploiting Modern CPUs. In 2010 Ninth International Workshop on Parallel and Distributed Methods in Verification and Second International Workshop on High Performance Computational Systems Biology (pp. 126 - 134 ). IEEE.

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