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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Kamma-Lorger, C. S., Boote, C., Hayes, S., Moger, J., Burghammer, M., Knupp, C., Quantock, A. J., Sorensen, T., Di Cola, E., White, N., Young, R. D. & Meek, K. M. (2010). Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology, 169(3), 424-30. https://doi.org/10.1016/j.jsb.2009.11.004

Poulsen, H. V., Canibe, N., Finster, K. & Jensen, B. B. (2010). Concentration of volatile sulphur-containing compounds along the gastrointestinal tract of pigs fed a high-sulphur or a low-sulphur diet. Livestock Science, 133(1-3), 128-131. https://doi.org/10.1016/j.livsci.2010.06.043

Nielsen, K. H. (2010). Confidentiality vs. publicity: Emerging tensions in military-science collaborations during the Cold War. Abstract from 4th International Conference of the European Society for the History of Science, Barcelona, Spain.

Ng, M. L., Balog, R., Hornekær, L., Preobrajenski, A. B., Vinogradov, N. A., Mårtensson, N. & Schulte, K. (2010). Controlling Hydrogenation of Graphene on Transition Metals. Journal of Physical Chemistry C, 114(43), 18559-18565 . https://doi.org/10.1021/jp106361y

Bayratarov, E., Finster, K., Price, R. E., Hubert, C. & Ferdelman, T. G. (2010). Controls on sulfate reduction in shallow submarine hydrothermal CO2-venting sediments. Poster session presented at European Geological Union Conference, Milos Island, Greece.

Mapendano, C. K., Lykke-Andersen, S., Kjems, J., Bertrand, E. & Jensen, T. H. (2010). Crosstalk between mRNA 3’ end processing and transcription initiation. Molecular Cell, 40, 410-422.

Hein, K. L., Kragh-Hansen, U., Morth, J. P., Jeppesen, M., Otzen, D., Møller, J. V. & Nissen, P. (2010). Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin. Journal of Structural Biology, 171, 353-360.

Pedersen, M. B., Zhou, X., Larsen, E. K. U., Sørensen, U. S., Kjems, J., Nygaard, J. V., Nyengaard, J. R., Meyer, R. L., Boesen, T. & Vorup-Jensen, T. (2010). Curvature of Synthetic and Natural Surfaces is an Important Target Feature in Classical Pathway Complement Activation. Journal of Immunology, 184(4), 1931-1945. https://doi.org/10.4049/jimmunol.0902214

Hjørringgaard, C. U., Vad, B., Nielsen, S. B., Matchkov, V., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2010). Cyclodextrin scaffolded alamethicin with highly efficient channel-forming properties. Journal of Peptide Science, 16, 148.

Hjørringgaard, C. U., Vad, B. S., Matchkov, V., Nielsen, S. B., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2010). Cyclodextrin Scaffolded Alamethicin with Highly Efficient Channel-forming Properties. Poster session presented at 31st European Peptide Symposium, 31EPS, Copenhagen, Denmark.

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Kalinka Hansen