Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. & Klostergaard, L. (2006). N-stråler, vands hukommelse og kold fusion: Naturvidenskabelige begrebers tilblivelse, tilintegørelse og translation. In C. Jantzen & T. Thellefsen (Eds.), Videnskabelig begrebsdannelse (pp. 53-74). Aalborg Universitetsforlag.

Friis, I. & Nielsen, K. H. (2006). Planter, dyr og forskere. In H. Nielsen & K. H. Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie (Vol. 4, pp. 125-146). Aarhus Universitetsforlag.

Nielsen, H. & Nielsen, K. H. (2006). Populærvidenskab fra forsker til folk. In H. Nielsen & K. H. Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie (Vol. 4, pp. 383-404). Aarhus Universitetsforlag.

Mailund , Brodal, G. S., Fagerberg, R., Pedersen, C. N. S. & Phillips, D. (2006). Recrafting the Neighbor-Joining Method. BMC Bioinformatics, 7(29).

Frandsen, J., Hobolth, A., Østergaard, L., Vestergaard-Poulsen, P. & Vedel, E. B. (2006). Regularization of Diffusion Tensor Fields in Axonal Fibre Tracking. Poster session presented at PhD Day 2006, The Faculty of Health Sciences, Aarhus, Denmark.

Howard, K. A., Rahbek, U. L., Liu, X., Damgaard, C. K., Glud, S. Z., Andersen, M. Ø., Hovgaard, M. B., Schmitz, A., Nyengaard, J. R., Besenbacher, F. & Kjems, J. (2006). RNA interference in Vitro and in Vivo using a novel chitosan/siRNA nanoparticle system. Molecular Therapy, 14(4), 476-484. https://doi.org/10.1016/j.ymthe.2006.04.010

Dong, M. (2006). Scanning probe microscopy studies of biomolecules on surfaces. Interdisciplinary Nanoscience Center (iNANO).

Birkedal, V., Krüger, A., Raarup, M. K., Kristensen, M., Kjems, J. & Besenbacher, F. (2006). Single molecule FRET microscopy on G-quadruplex DNA structures. Poster session presented at Single Molecule Picoquant Workshop, Berlin, Germany.

Krüger, A., Birkedal, V., Raarup, M. K., Kristensen, M., Kjems, J. & Besenbacher, F. (2006). Single-molecule Microscopy on Nucleic Acids. Poster session presented at NANOBIO Summer School "The live cell from nano to micro", Cargese, Corse, France.

Kjems, J. & Wengel, J. (2006). Small internally segmented interfering RNA.

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