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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. (2025). Myten om Silkevejen. Weekendavisen, Sektion 4 (Ideer), 5.

Boonkaew, S., Teodori, L., Vendelbo, M. H., Kjems, J. & Ferapontova, E. E. (2025). Nanobodies' duo facilitates ultrasensitive serum HER-2/neu immunoassays via enhanced avidity interactions. Analytica Chimica Acta, 1335, Article 343472. https://doi.org/10.1016/j.aca.2024.343472

Nielsen, J., Pedersen, J. N., Kleijwegt, G., Nowak, J. S., Nami, F., Johansen, C., Sassetti, E., Berg, B. B., Lyngsø, N. M., Brøchner, B. H., Holm Carlson, J., Simonsen, A. J., Pallisgaard Olsen, W., Simonsen, B. W., Mikkelsen, J. H., Sereika-Bejder, V., Lauritsen, J. A., Merrild, K. F., Malle, M. G. ... Otzen, D. E. (2025). Nanobodies raised against the cytotoxic α-synuclein oligomer are oligomer-specific and promote its cellular uptake. npj biosensing, 2, Article 23. https://doi.org/10.1038/s44328-025-00042-1

Hemmingsen, J. K., Whitehead, B., Howard, K. & Nejsum, P. L. (2025). Nanobudbringere til hjernen: Et nyt våben mod sclerose. Aktuel Naturvidenskab, 2025(4).

Teodori, L., Shahrokhtash, A., Sørensen, E. A., Zhang, X., Malle, M. G., Sutherland, D. S. & Kjems, J. (2025). Nanoscale Precise Stamping of Biomolecule Patterns Using DNA Origami. ACS Nano, 19(42), 36931-36942. https://doi.org/10.1021/acsnano.5c07651

Peña Díaz, S., Zhang, Z., Jiang, Y., Daugberg, A. O. H., López Hernández, M., Nielsen, J., Dueholm, M. K. D., Dong, MD., Pedersen, J. S., Otzen, D. E. & Wang, H. (2025). Natural Design of a Stabilized Cross-β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats. Advanced Materials, 37(34), Article 2505503. https://doi.org/10.1002/adma.202505503

Andersen-Civil, A. I. S., Mantel, M., Soh, J., Mostowy, S., Brugman, S. & Vanwalleghem, G. C. (2025). Novel and unscrutinized immune entities of the zebrafish gut. FEBS Letters, 599(23), 3444-3455. https://doi.org/10.1002/1873-3468.70161

Egendal, I., Brøndum, R. F., Pelizzola, M., Hobolth, A. & Bøgsted, M. (2025). On the Relation Between Linear Autoencoders and Non-Negative Matrix Factorization for Mutational Signature Extraction. Journal of computational biology : a journal of computational molecular cell biology, 32(5), 461-472. https://doi.org/10.1089/cmb.2024.0784

Hirsch, C. & Juhasz, P. (2025). On the Topology of Higher-order Age-dependent Random Connection Models. Methodology and Computing in Applied Probability, 27(2), Article 44. https://doi.org/10.1007/s11009-025-10173-7

Nielsen, K. H. (2025). Oppenheimers sande ansigt. Weekendavisen, Sektion 4 (Ideer), 5.

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Kalinka Hansen