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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Hansen, T. B., Venø, M. T., Kjems, J. & Damgaard, C. K. (2014). miRdentify: high stringency miRNA predictor identifies several novel animal miRNAs. Nucleic Acids Research, 42(16), 1-11. Article e124. https://doi.org/10.1093/nar/gku598

Nielsen, K. H. (2014). Moder natur som våben. Videnskab.dk. http://videnskab.dk/blog/moder-natur-som-vaben

Li, Q., Liu, L., Zhang, S., Xu, M., Wang, X., Wang, C., Besenbacher, F. & Dong, MD. (2014). Modulating Aβ_33-42 Peptide Assembly by Graphene Oxide. Chemistry: A European Journal, 20(24), 7236-7240. https://doi.org/10.1002/chem.201402022

Ling, M., Santl-Temkiv, T., Finster, K. & Boesen, T. (2014). Molecular and physical characterization of bacterial ice nucleation proteins provide an insight into their biosignature potential.. Poster session presented at Joint Meeting of the Nordic Network of Astrobiology and the Centre of Geobiology, University of Bergen, Bergen, Norway.

Liu, L., Niu, L., Xu, M., Han, Q., Duan, H., Dong, MD., Besenbacher, F., Wang, C. & Yang, Y. (2014). Molecular Tethering Effect of C-Terminus of Amyloid Peptide Aβ42. A C S Nano, 8(9), 9503-9510. https://doi.org/10.1021/nn503737r

Nielsen, K. H., Nielsen, K. & Heymann, M. (2014). Molekylærmedicinens videnskabsteori og etik. Poster session presented at 1st Annual Meeting of the Danish Network in Philosophy of Science, Odense, Denmark.

Thomsen, T. B., Li, L. & Howard, K. (2014). Mucus barrier-triggered disassembly of siRNA nanocarriers. Nanoscale, 6(21), 12547-54. https://doi.org/10.1039/c4nr01584c

Lü, J., Yang, J., Dong, MD. & Sahin, O. (2014). Nanomechanical spectroscopy of synthetic and biological membranes. Nanoscale, 6(13), 7604-7608. https://doi.org/10.1039/c3nr02643d

Nørby, P., Overgaard, J., Sigaard Christensen, P., Richter, B., Song, X., Dong, MD., Han, A., Skibsted, J., Iversen, B. B. & Johnsen, S. (2014). (NH₄)₄Sn₂S₆·3H ₂O: Crystal structure, thermal decomposition, and precursor for textured thin film. Chemistry of Materials, 26(15), 4494-4504. https://doi.org/10.1021/cm501681r

Kjems, J., Ferapontova, E. & Gothelf, K. V. (Eds.) (2014). Nucleic Acid Nanotechnology. Springer. Nucleic Acids and Molecular Biology Vol. 29 https://doi.org/10.1007/978-3-642-38815-6

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Kalinka Hansen