Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

Sort by: Date | Author | Title

Dunn, T. H., Skaanvik, S. A., McPherson, I. J., O’Shaughnessy, C., He, X., Kulak, A. N., Micklethwaite, S., Matamoros-Veloza, A., Sandei, I., Hunter, L., Turner, T. D., Galloway, J. M., Rosenthal, M., Britton, A. J., Walker, M., Dong, M., Unwin, P. R. & Meldrum, F. C. (2023). Universality of Hair as a Nucleant: Exploring the Effects of Surface Chemistry and Topography. Crystal Growth and Design, 23(12), 8978-8990. https://doi.org/10.1021/acs.cgd.3c01035

Nielsen, K. H. (2023). USAs skæbneår. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2023). Verdens ældste pyramide. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2023). Virologer på vildspor. Weekendavisen, Sektion 4 (Ideer), 5.

Jensen, B. N., Wang, Y., Friec, A. L., Nabavi, S. . M. . S., Dong, MD., Seliktar, D. & Chen, M. (2023). Wireless electromagnetic neural stimulation patch with anisotropic guidance. npj Flexible Electronics, 7(1), Article 34. https://doi.org/10.1038/s41528-023-00270-3

Andersen-Civil, A. I. S., Sawale, R. A. & Vanwalleghem, G. C. (2023). Zebrafish (Danio rerio) as a translational model for neuro-immune interactions in the enteric nervous system in autism spectrum disorders. Brain, Behavior, and Immunity, 112, 254-266. https://doi.org/10.1016/j.bbi.2023.06.001

Mahato, M., Hwang, W. J., Tabassian, R., Oh, S., Nguyen, V. H., Nam, S., Kim, J. S., Yoo, H., Taseer, A. K., Lee, M. J., Zhang, H., Song, T. E. & Oh, I. K. (2022). A Dual-Responsive Magnetoactive and Electro–Ionic Soft Actuator Derived from a Nickel-Based Metal–Organic Framework. Advanced Materials, 34(35), Article 2203613. https://doi.org/10.1002/adma.202203613

Zhu, X., Wang, Z., Gao, M., Wang, Y., Hu, J., Song, Z., Wang, Z. & Dong, M. (2022). AgPt/MoS₂ hybrid as electrochemical sensor for detecting H₂O₂ release from living cells. New Journal of Chemistry, 46(31), 15032-15041. https://doi.org/10.1039/d2nj02495k

Yang, E., Metzloff, M., Langmüller, A. M., Xu, X., Clark, A. G., Messer, P. W. & Champer, J. (2022). A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles. G3: Genes, Genomes, Genetics, 12(6), Article jkac081. https://doi.org/10.1093/g3journal/jkac081

Dinesen, A., Winther, A., Wall, A., Märcher, A., Palmfeldt, J., Chudasama, V., Wengel, J., Gothelf, K. V., Baker, J. R. & Howard, K. A. (2022). Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly. Bioconjugate Chemistry, 33(2), 333-342. https://doi.org/10.1021/acs.bioconjchem.1c00561

Displaying results 551 to 560 out of 3464