Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. (2014). 1819 - Damp. In Danmark bliver Danmark: Kamp, damp og genier i 1800-tallet (pp. 19). Aarhus Universitetsforlag.

Nielsen, K. H. (2014). 1846 Ekspedition. Jyllands-Posten, 11.

Nielsen, K. H. (2014). 1846 - Ekspedition. In Danmark bliver Danmark: Kamp, damp og genier i 1800-tallet (pp. 46). Aarhus Universitetsforlag.

Nielsen, K. H. (2014). 1847 Industri. Jyllands-Posten, 5.

Nielsen, K. H. (2014). 1847 - Industri. In Danmark bliver Danmark: Kamp, damp og genier i 1800-tallet (pp. 47). Aarhus Universitetsforlag.

Kaalund, S. S., Venø, M. T., Bak, M., Møller, R. S., Laursen, H., Madsen, F., Broholm, H., Quistorff, B., Uldall, P., Tommerup, N., Kauppinen, S., Sabers, A., Fluiter, K., Møller, L. B., Nossent, A. Y., Silahtaroglu, A., Kjems, J., Aronica, E. & Tümer, Z. (2014). Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance. Epilepsia, 55(12), 2017-2027. https://doi.org/10.1111/epi.12839

Wittenborn, T. R., Larsen, E. K. U., Nielsen, T., Rydtoft, L. M., Hansen, L., Nygaard, J. V., Vorup-Jensen, T., Kjems, J., Horsman, M. R. & Nielsen, N. C. (2014). Accumulation of nano-sized particles in a murine model of angiogenesis. Biochemical and Biophysical Research Communications, 443(2), 470-6. https://doi.org/10.1016/j.bbrc.2013.11.127

Brereton, T., Hirsch, C., Schmidt, V. & Kroese, D. (2014). A critical exponent for shortest-path scaling in continuum percolation. Journal of Physics A: Mathematical and Theoretical, 47(50), 505003.

He, Y., Zhang, P., Hou, X., Xu, J., Wang, M., Wu, Y., Qu, J. & Dong, MD. (2014). Adjusting the electronic properties of silicon carbide nanoribbons by introducing edge functionalization. R S C Advances, 4(66), 35042-35047. https://doi.org/10.1039/c4ra04351k

Nielsen, C., Kjems, J., Sorensen, K. R., Engelholm, L. H. & Behrendt, N. (2014). Advances in targeted delivery of small interfering RNA using simple bioconjugates. Expert Opinion on Drug Delivery, 11(5), 791-822. https://doi.org/10.1517/17425247.2014.896898

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