Find

AUNAB - Aarhus University Network on Artificial Biology

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

Sort by: Date | Author | Title

Qian, X., Nymann Westensee, I., Brodszkij, E. & Städler, B. (2021). Cell mimicry as a bottom-up strategy for hierarchical engineering of nature-inspired entities. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 13(3), Article e1683. https://doi.org/10.1002/wnan.1683

Walther, R., Huynh, T. H., Monge, P., Fruergaard, A. S., Mamakhel, A. & Zelikin, A. N. (2021). Ceria Nanozyme and Phosphate Prodrugs: Drug Synthesis through Enzyme Mimicry. ACS Applied Materials & Interfaces, 13(22), 25685-25693. https://doi.org/10.1021/acsami.1c03890

Moldovan, L. I., Tsoi, L. C., Ranjitha, U., Hager, H., Weidinger, S., Gudjonsson, J. E., Kjems, J. & Kristensen, L. S. (2021). Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles. Experimental Dermatology, 30(8), 1187-1196. https://doi.org/10.1111/exd.14227

Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H., Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P., Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021). Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. Proceedings of the National Academy of Sciences (PNAS), 118(30), Article e2106647118. https://doi.org/10.1073/pnas.2106647118

Gruenberg, M., Irla, M., Myllek, S. & Draths, K. (2021). Characterization of two 3-deoxy-D-Arabino-Heptulosonate 7-phosphate synthases from Bacillus methanolicus. Protein Expression and Purification, 188, Article 105972. https://doi.org/10.1016/j.pep.2021.105972

Walther, R. & Zelikin, A. N. (2021). Chemical (neo)glycosylation of biological drugs. Advanced Drug Delivery Reviews, 171, 62-76. https://doi.org/10.1016/j.addr.2021.01.021

Garcia Soriano, D. A., Andersen, F. D., Nygaard, J. V. & Tørring, T. (2021). ColFeatures: Automated data extraction and classification of bacterial colonies. bioRxiv. https://doi.org/10.1101/2021.05.27.445853

Mancienne, T., Marquez-Legorreta, E., Wilde, M., Piber, M., Favre-Bulle, I., Vanwalleghem, G. & Scott, E. K. (2021). Contributions of Luminance and Motion to Visual Escape and Habituation in Larval Zebrafish. Frontiers in Neural Circuits, 15, Article 748535. https://doi.org/10.3389/fncir.2021.748535

Dai, R., Liu, B., Zhang, Y., Pedersen, J. N., Zhang, X., Dong, M. & Guo, Z. (2021). Copper-based ternary hydrotalcite as a catalyst for hydroxylation of phenolic compounds. Journal of Environmental Chemical Engineering, 9(6), Article 106390. https://doi.org/10.1016/j.jece.2021.106390

Amodeo, G. F., Lee, B. Y., Krilyuk, N., Filice, C. T., Valyuk, D., Otzen, D. E., Noskov, S., Leonenko, Z. & Pavlov, E. V. (2021). C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition. Scientific Reports, 11(1), Article 8744. https://doi.org/10.1038/s41598-021-88157-z

Displaying results 761 to 770 out of 3464

77

Revised 03.03.2026

-

Kalinka Hansen