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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Chen, M., Gao, S., Dong, M., Song, J., Yang, C., Howard, K. A., Kjems, J. & Besenbacher, F. (2012). Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. A C S Nano, 6(6), 4835-4844. https://doi.org/10.1021/nn300106t

Liu, P., Zhang, S., Chen, M.-S., Liu, Q., Wang, C., Wang, C., Li, Y.-M., Besenbacher, F. & Dong, M. (2012). Co-assembly of human islet amyloid polypeptide (hIAPP)/insulin. Chemical Communications, 48(2), 191-193. https://doi.org/10.1039/c1cc14285b

Li, Y., Guo, L., Liu, B., Mamdouh, W., Zhang, S. & Dong, M. (2012). Collagen coated tantalum substrate for cell proliferation. Colloids and Surfaces B: Biointerfaces, 95, 10-15. https://doi.org/10.1016/j.colsurfb.2012.01.009

Jakob, T., Köhler, J., Blank, S., Spillner, E., Magnusson, U., Lidholm, J. & Huss-Marp, J. (2012). Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy. Journal of Allergy and Clinical Immunology, 130(1), 276-278. https://doi.org/10.1016/j.jaci.2012.03.048

Østergaard, T., Sørensen, B. S., Sørensen, S. & Kjems, J. (2012). Composition useful as a medicament for treating cancer and/or neuropsychiatric disorders, comprises a binding member capable of binding to a human epidermal growth factor (EGF) receptor 4 (HER4) polypeptide and/or a HER4 RNA. (Patent No. WO2011107100-A1 ).

Nielsen, K. H. (2012). Confidentiality vs. publicity: Emerging tensions in science and technology during the Cold War. In A. Roca-Rosell (Ed.), The Circulation of Science and Technology: Proceedings of the 4th International Conference of the ESHS, Barcelona, 18-20 November 2010 (pp. 869-874). Societat Catalana d‘Història de la Ciència i de la Tècnica (SCHCT). http://taller.iec.cat/4iceshs/documentacio/P4ESHS.pdf

Zadegan, R. M., Jepsen, M. DE., Thomsen, K. E., Okholm, A. H., Schaffert, D. H., Andersen, E. S., Birkedal, V. & Kjems, J. (2012). Construction of a 4 Zeptoliters Switchable 3D DNA Box Origami. A C S Nano, 6(11), 10050-10053. https://doi.org/10.1021/nn303767b

Nielsen, K. H. (2012). Contextualising strategic communication of science and technology: persuasion, organization, public relations. In M. Bucchi & B. Trench (Eds.), Quality, Honesty and Beauty in Science and Technology Communication: 12th International Public Communication of Science and Technology Conference. Book of Papers (pp. 105-108). Observa Science in Society. http://www.pcst2012.org/images/PCST2012_Book_of_Papers.pdf

Li, Y., Yu, Y., Wang, J.-G., Song, J., Li, Q., Dong, M. & Liu, C.-J. (2012). CO oxidation over graphene supported palladium catalyst. Applied Catalysis B: Environment and Energy, 125, 189-196. https://doi.org/10.1016/j.apcatb.2012.05.023

Dueholm, M. S., Albertsen, M., Otzen, D. & Nielsen, P. H. (2012). Curli functional amyloid systems are phylogenetically widespread and display large diversity in operon and protein structure. PLoS One, 7(12), e51274. https://doi.org/10.1371/journal.pone.0051274

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Kalinka Hansen