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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Song, Y., Dai, B., Wang, Y., Wang, Y., Gourdon, P., Liu, L., Wang, K. & Dong, M. (2022). Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation. Nano Letters, 22(9), 3707-3712. https://doi.org/10.1021/acs.nanolett.2c00596

Rasmussen, H. Ø., Otzen, D. E. & Pedersen, J. S. (2022). Induction, inhibition, and incorporation: Different roles for anionic and zwitterionic lysolipids in the fibrillation of the functional amyloid FapC. The Journal of Biological Chemistry, 298(2), Article 101569. https://doi.org/10.1016/j.jbc.2022.101569

Zhang, M., Zhang, Y., Mu, W., Dong, M. & Han, X. (2022). In Situ Synthesis of Lipid Analogues Leading to Artificial Cell Growth and Division. ChemSystemsChem, 4(4), Article 202200007. https://doi.org/10.1002/syst.202200007

Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Pedersen, J. S., Nielsen, J. & Otzen, D. E. (2022). Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation. BBA advances, 2, Article 100055. https://doi.org/10.1016/j.bbadva.2022.100055

Zhu, X., Wang, Z., Hu, J., Lu, Z., Gao, M., Wang, Y., Song, Z., Dong, M., Wang, Z. & Klausen, L. H. (2022). Ion-modulated photoluminescence of MoS₂ nanoflakes for cell viability detection. New Journal of Chemistry, 46(46), 22441-22450. https://doi.org/10.1039/d2nj04073e

Nielsen, K. H. (2022). Kræftfremkaldende babypudder. Weekendavisen, Sektion 4 (Ideer), 13.

Nielsen, K. H. (2022). Læk fra laboratoriet. Weekendavisen, Sektion 4 (Ideer), 5.

Eriksen, C. B. (2022). Leeuwenhoek, Antoni van. In D. Jalobeanu & C. T. Wolfe (Eds.), Encyclopedia of Early Modern Philosophy and the Sciences (pp. 1068-1070). Springer.

Reimer, L., Haikal, C., Gram, H., Theologidis, V., Kovacs, G., Ruesink, H., Baun, A., Nielsen, J., Otzen, D. E., Li, J.-Y. & Jensen, P. H. (2022). Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein. Scientific Reports, 12, Article 3737. https://doi.org/10.1038/s41598-022-07706-2

Groß, R., Dias Loiola, L. M., Issmail, L., Uhlig, N., Eberlein, V., Conzelmann, C., Olari, L. R., Rauch, L., Lawrenz, J., Weil, T., Müller, J. A., Cardoso, M. B., Gilg, A., Larsson, O., Höglund, U., Pålsson, S. A., Tvilum, A. S., Løvschall, K. B., Kristensen, M. M. ... Münch, J. (2022). Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2. Advanced Science, 9(20), Article 2201378. https://doi.org/10.1002/advs.202201378

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Kalinka Hansen