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Recent research news on Artificial Biology

Single Protein-Mediated Vesicle Division

Steering group member of AUNAB, Prof. Brigitte Städler, has published a collaborative study in Advanced Materials on the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles.

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Jiang, A., Chen, C., Feng, J., Li, Q., Liu, W. & Dong, M. (2025). Boosting electrocatalytic hydrogen evolution via partial oxidation of rhenium through cobalt modification in nanoalloy structure. Journal of Colloid and Interface Science, 677(Part B), 617-625. https://doi.org/10.1016/j.jcis.2024.08.084
Teixeira, L. M. C., Paiva, P., Ferreira, P., Rotilio, L., Morth, J. P., Otzen, D. E., Fernandes, P. A. & Ramos, M. J. (2025). Bridging experiment and theory: a computational exploration of UMG-SP3 dynamics. Pure and Applied Chemistry, 97(10), 1405-1418. https://doi.org/10.1515/pac-2025-0489
García-Rodríguez, J. L., Korsgaard, U., Vissing, S. M., Paasch, T. P., Semenova, M., Vendelbo, S. L., Jensby, E. F., Williams, H. L., Salachan, P. V., Brandt, C. B., Hanimann, J., Lin, L., Zlobec, I., Sørensen, K. D., Kjems, J., Hager, H. & Kristensen, L. S. (2025). Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer. Communications Biology, 8(1), Article 1345. https://doi.org/10.1038/s42003-025-08799-x
Langmüller, A. M., Hermisson, J., Murdock, C. & Messer, P. W. (2025). Catching a wave: On the suitability of traveling-wave solutions in epidemiological modeling. Theoretical Population Biology, 162, 1-12. https://doi.org/10.1016/j.tpb.2024.12.004
De Dios Andres, P., Pendlmayr, S., Gal, N., Abild Meyer, C., Ryberg, C., Vestrheim, O., Kalacas, N. A., Demir, F., Rinschen, M. M., Haupt, K., Mookerjee, R. P. & Städler, B. (2025). Cell Membrane Vesicle Camouflaged Artificial Cells. Advanced Functional Materials, 35(30), Article 2424504. https://doi.org/10.1002/adfm.202424504
Paasch, T. P., Olesen, M. T. J., García-Rodríguez, J. L., Assmus, A. M., Fenton, R. A., Kjems, J., Hager, H. & Kristensen, L. S. (2025). ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. PLoS Genetics, 21(6), Article e1011726. https://doi.org/10.1371/journal.pgen.1011726
Slumstrup, L., Thrower, J. D., Hopkinson, A. T., Wenzel, G., Jaganathan, R., Schrauwen, J. G. M., Redlich, B., Ioppolo, S. & Hornekær, L. (2025). CO desorption from interstellar icy grains induced by infrared excitation of superhydrogenated polycyclic aromatic hydrocarbons. Astronomy and Astrophysics, 704, Article A74. https://doi.org/10.1051/0004-6361/202556399
Slumstrup, L., Thrower, J. D., Hopkinson, A. T., Wenzel, G., Jaganathan, R., Schrauwen, J. G. M., Redlich, B., Ioppolo, S. & Hornekær, L. (2025). CO desorption from interstellar icy grains induced by IR excitation of superhydrogenated PAHs.
Bendtsen, M. K., Nowak, J. S., Paiva, P., López Hernández, M., Ferreira, P., Pedersen, J. S., Bekker, N. S., Viezzi, E., Bisiak, F., Brodersen, D. E., Pedersen, L. H., Zervas, A., Fernandes, P. A., Ramos, M. J., Stougaard, P., Thøgersen, M. S. & Otzen, D. E. (2025). Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca2+ Ions and Conformational Dynamics in Psychrophilicity. Biomolecules, 15(3), Article 415. https://doi.org/10.3390/biom15030415
Fage-Butler, A., Nielsen, K. H. & Ledderer, L. K. (2025). Conclusion. In Science communication and trust (pp. 493-509). Palgrave Macmillan. https://doi.org/10.1007/978-981-96-1289-5_24

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Revised 03.03.2026
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Kalinka Hansen