Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

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Fage-Butler, A., Nielsen, K. H., Ledderer, L. K., Tørring, M. L. & Nielbo, K. L. (2022). Exploring public trust and mistrust relating to the MMR vaccine in Danish newspapers using computational analysis and framing analysis. Abstract from Digital Humanities in the Nordic and Baltic Countries Conference (DHNB 2022), Uppsala, Sweden.

Fage-Butler, A., Nielsen, K. H., Ledderer, L. K., Tørring, M. L. & Nielbo, K. L. (2022). Exploring Trust and Mistrust Relating to the MMR Vaccine in Danish Newspapers Using Computational Analysis and Framing Analysis. In Proceedings of the 6th Digital Humanities in the Nordic and Baltic Countries Conference (DHNB 2022) (Vol. 3232, pp. 212-220). CEUR-WS.org. http://ceur-ws.org/Vol-3232/paper18.pdf

Gomes-Duarte, A., Venø, M. T., de Wit, M., Senthilkumar, K., Broekhoven, M. H., van den Herik, J., Heeres, F. R., van Rossum, D., Rybiczka-Tesulov, M., Legnini, I., van Rijen, P. C., van Eijsden, P., Gosselaar, P. H., Rajewsky, N., Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2022). Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology. Frontiers in Molecular Neuroscience, 15, Article 832133. https://doi.org/10.3389/fnmol.2022.832133

Dahl, M., Husby, S., Eskelund, C. W., Besenbacher, S., Fjelstrup, S., Côme, C., Ek, S., Kolstad, A., Räty, R., Jerkeman, M., Geisler, C. H., Kjems, J., Kristensen, L. S. & Grønbæk, K. (2022). Expression patterns and prognostic potential of circular RNAs in mantle cell lymphoma: a study of younger patients from the MCL2 and MCL3 clinical trials. Leukemia, 36(1), 177-188. https://doi.org/10.1038/s41375-021-01311-4

Østergaard, R. H., Yan, Y., Venø, M. T., Dinesen, A., Kjaer-Sorensen, K., Oxvig, C., Rasmussen, J. T., Howard, K., Kjems, J., van Niel, G., Verweij, F. & Hayashi, Y. (2022). Extracellular Vesicle Biology Meets Zebrafish: Real-Time Visualization and RNA Profiling of Physiological Exosomes in the Bloodstream. Poster session presented at The Danish Society for Extracellular Vesicles (DSEV) 3rd Annual Symposium 2022, Roskilde, Denmark.

Chenavier, N. & Hirsch, C. (2022). Extremal lifetimes of persistent cycles. Extremes, 25(2), 299-330. https://doi.org/10.1007/s10687-021-00430-6

Heydenreich, M. & Hirsch, C. (2022). Extremal linkage networks. Extremes, 25(2), 229-255. https://doi.org/10.1007/s10687-021-00433-3

Song, P., Staulund, J., Qi, H., Thrane, L., Pedersen, M., Eijken, M., Jespersen, B. & Kjems, J. (2022). Ex-vivo mRNA therapy to predict kidney vitality during transplantation. Poster session presented at Danish RNA Society's 7th Annual Meeting, Aarhus, Denmark.

Wang, D., Wang, Z., Yang, Z., Wang, S., Tan, C., Yang, L., Hao, X., Ke, Z. & Dong, M. (2022). Facile damage-free double exposure for high-performance 2D semiconductor based transistors. Materials Today Physics, 24, Article 100678. https://doi.org/10.1016/j.mtphys.2022.100678

Nielsen, K. H. (2022). Feministisk forskning. Weekendavisen, Sektion 4 (Ideer), 13.

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