Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. (2017). Camp Century's Degrees of Coldness: From Cold War Icon to Climate Change-Induced Problem. Nach Feierabend. Zürcher Jahrbuch für Wissensgeschichte, 13, 17-37.

Okholm, T. L. H., Nielsen, M. M., Hamilton, M., Christensen, L.-L., Vang, S., Hedegaard, J., Hansen, T. B., Kjems, J., Dyrskjøt, L. & Pedersen, J. S. (2017). Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. npj Genomic Medicine, 2(1), Article 36. https://doi.org/10.1038/s41525-017-0038-z

Yan, Y., Wang, X., Venø, M. T., Bakholdt, V., Sørensen, J. A., Krogdahl, A., Sun, Z., Gao, S. & Kjems, J. (2017). Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients. OncoTarget, 8(5), 8206-8214. https://doi.org/10.18632/oncotarget.14143

Eriksen, C. B. (2017). Circulation of Blood and Money in Leviathan - Hobbes on the Economy of the Body. In J. Bek-Thomsen, C. Olaf Christiansen, S. Gaardsmand Jacobsen & M. Thorup (Eds.), Ethical Economy: Economic Reasoning as Knowledge and Practice Authority (pp. 31-41). Springer. https://doi.org/10.1007/978-3-319-52815-1_4

Nielsen, K. H. (2017). Cod Society: The Technopolitics of Modern Greenland. In L.-A. Körber, S. MacKenzie & A. W. Stenport (Eds.), Arctic Environmental Modernities: From the Age of Polar Exploration to the Era of the Anthropocene (1 ed., pp. 71-85). Palgrave Macmillan.

Jakob, T. & Spillner, E. (2017). Comparing sensitivity of Hymenoptera allergen components on different diagnostic assay systems: Comparing apples and oranges. Journal of Allergy and Clinical Immunology, 139(3), 1066-1067. https://doi.org/10.1016/j.jaci.2016.09.058

Domljanovic, I., Carstens, A., Okholm, A., Kjems, J., Nielsen, C. T., Heegaard, N. H. H. & Astakhova, K. (2017). Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies. Scientific Reports, 7(1), Article 1925. https://doi.org/10.1038/s41598-017-02214-0

Jakob, T., Müller, U., Helbling, A. & Spillner, E. (2017). Component resolved diagnostics for Hymenoptera venom allergy. Current Opinion in Allergy and Clinical Immunology, 17(5), 363-372. https://doi.org/10.1097/ACI.0000000000000390

Sparvath, S. L., Geary, C. W. & Andersen, E. S. (2017). Computer-aided design of RNA origami structures. Methods in Molecular Biology, 1500, 51-80. https://doi.org/10.1007/978-1-4939-6454-3_5

Manuguerra, I., Grossi, G., Thomsen, R. P., Lyngsø, J., Pedersen, J. S., Kjems, J., Andersen, E. S. & Gothelf, K. V. (2017). Construction of a Polyhedral DNA 12-Arm Junction for Self-Assembly of Wireframe DNA Lattices. A C S Nano, 11(9), 9041-9047. https://doi.org/10.1021/acsnano.7b03538

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