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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Rahimi, K., Venø, M. T., Dupont, D. M. & Kjems, J. (2021). Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons. Nature Communications, 12, Article 4825. https://doi.org/10.1038/s41467-021-24975-z

Nielsen, K. H. (2021). Newtons mobbekampagne. Weekendavisen, (Sektion 4 (Ideer)), 5.

Lisi, F., Zelikin, A. N. & Chandrawati, R. (2021). Nitric Oxide to Fight Viral Infections. Advanced Science, 8(7), Article 2003895. https://doi.org/10.1002/advs.202003895

Dormann, F., Frisk, O., Andersen, L. N. & Pedersen, C. F. (2021). Not All Noise Is Accounted Equally: How Differentially Private Learning Benefits From Large Sampling Rates. In 2021 IEEE 31st International Workshop on Machine Learning for Signal Processing, MLSP 2021 IEEE. https://doi.org/10.1109/MLSP52302.2021.9596307

Błaszczyszyn, B. & Hirsch, C. (2021). Optimal stationary markings. Stochastic Processes and Their Applications, 138, 153-185. https://doi.org/10.1016/j.spa.2021.04.003

Nielsen, K. H. (2021). Panodiler til gravide. Weekendavisen, (Sektion 4 (Ideer)), 5. https://www.weekendavisen.dk/2021-40/ideer/panodiler-til-gravide

Xu, R., Li, S., Shi, M., Li, Z., Wang, Y., Li, J., Li, Q., Klausen, L. H., Li, A., Zhao, H., Chen, M., Hu, J., Dong, MD. & Li, N. (2021). Peptide-based high-density lipoprotein promotes adipose tissue browning and restrains development of atherosclerosis and type 2 diabetes. Nano Today, 36, Article 101054. https://doi.org/10.1016/j.nantod.2020.101054

Walther, R., Monge, P., Pedersen, A., Benderoth, A., Pedersen, J., Farzadfard, A., Mandrup, O., Howard, K., Otzen, D. & Zelikin, A. N. (2021). Per-glycosylation of the Surface-Accessible Lysines: One-Pot Aqueous Route to Stabilized Proteins with Native Activity. ChemBioChem, 22(14), 2478-2485. https://doi.org/10.1002/cbic.202100228

Dichmann, L. P., Bregnhøj, M., Liu, H., Westberg, M., Poulsen, T., Etzerodt, M. & Ogilby, P. R. (2021). Photophysics of a Protein-Bound Derivative of Malachite Green that Sensitizes the Production of Singlet Oxygen. Photochemical & Photobiological Sciences, 20(3), 435-449. https://doi.org/10.1007/s43630-021-00032-y

Andersen, C. & Nielsen, K. H. (2021). Postkoloniale STS-studier. In P. Danholt & C. Gad (Eds.), Videnskab, teknologi og samfund: En introduktion til STS (pp. 201-220). Hans Reitzels Forlag.

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Kalinka Hansen