Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, J., Pedersen, C. S. & Hein, J. (2009). Investigation of a simple heuristic improving the speed of statistical alignments. Poster session presented at 17th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 8th European Conference on Computational Biology (ECCB), Stockholm, Sweden.

Nesgaard, L. W., Vad, B., Christiansen, G. & Otzen, D. (2009). Kinetic partitioning between aggregation and vesicle permeabilization by modified ADan. Biochimica et Biophysica Acta. Molecular Cell Research, 1794, 84-93.

Nielsen, K. H. (2009). Klamphuggeri. Hvem definerer god forskning? Politiken, 8.

Nielsen, K. H. (2009). Lær af de russiske forandringer. Videnskab.dk.

Kristensen, T. G., Pedersen, C. S., Thomsen, R. & Christensen, M. H. (2009). Largest Common Chemical Feature Subtree as a Virtual Screening Method. Poster session presented at 17th Annual International Conference on Intelligent Systems for Molecular Bioligy (ISMB) & 8th European Conference on Computational Biology (ECCB), Stockholm, Sweden. http://www.iscb.org/ismbeccb2009/poster_list.php?cat=C

Nevo, I., Kapishnikov, S., Birman, A., Dong, M., Cohen, S. R., Kjaer, K., Besenbacher, F., Stapelfeldt, H., Seideman, T. & Leiserowitz, L. (2009). Laser-induced aligned self-assembly on water surfaces. Journal of Chemical Physics, 130(14), 144704. https://doi.org/10.1063/1.3108540

Basse-O'Connor, A. & Pedersen, J. (2009). Lévy driven moving averages and semimartingales. Stochastic Processes and Their Applications, 119(9), 2970-2991. https://doi.org/10.1016/j.spa.2009.03.007

Andersen, L. N. & Asmussen, S. (2009). Local time asymptotics for centered Lévy processes with two-sided reflection. Thiele Centre, Institut for Matematiske Fag, Aarhus Universitet.

Andersen, L. N. (2009). Loss Rates and Structural Properties of Reflected Stochastic Processes. Aarhus Universitetsforlag.

Dong, M. (Ed.) (2009). Materials Special Issue: Nanomaterials. In Mangler titel

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