Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. (2015). Nanoteknologi. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 311-315). Aarhus Universitetsforlag.

Eriksen, C. B. (2015). Naturhistoriens bestyrer: Efterskrift til Buffons 'Første afhandling'. Ny Jord - Tidsskrift for naturkritik, 1, 45-54.

Besenbacher, S., Liu, S., Izarzugaza, J. M. G., Grove, J., Belling, K., Bork-Jensen, J., Huang, S., Als, T. D., Li, S., Yadav, R., Rubio-García, A., Lescai, F., Demontis, D., Rao, J., Ye, W., Mailund, T., Møllegaard Friborg, R., Pedersen, C. N. S., Xu, R. ... Rasmussen, S. (2015). Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios. Nature Communications, 6, Article 5969. https://doi.org/10.1038/ncomms6969

Meedom, P. J., Carstensen, J., Eriksen, C. B. & Vermehren Holm, A. (Eds.) (2015). Ny Jord - Tidsskrift for naturkritik: Nr. 1. Forlaget Virkelig.

Finster, K. (2015, Nov 10). Ny teori: Livet kan sprede sig som virus i galaksen.

Nielsen, K. H. (2015). Olie. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 165-169). Aarhus Universitetsforlag.

Basse-O'Connor, A. & Rosiński, J. (2015). On infinitely divisible semimartingales. Probability Theory and Related Fields, 164(1-2), 133-163. https://doi.org/10.1007/s00440-014-0609-1

Nielsen, K. H. (2015). On the prowl for pollution: Environmental activists and citizen science in 1980’s Denmark. Abstract from 4S Annual Meeting, Denver, Colorado, United States.

Nielsen, K. H. (2015). Opfindelsernes verden. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 317-323). Aarhus Universitetsforlag.

Jakob, T., Blank, S. & Spillner, E. (2015). Optimierte Diagnostik der Insektengiftallergie durch rekombinante Allergene. In J. Kleine-Tebbe & T. Jakob (Eds.), Molekulare Allergiediagnostik (pp. 257-275). Springer. https://doi.org/10.1007/978-3-662-45221-9_16

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