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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Basse-O'Connor, A., Graversen, S.-E. & Pedersen, J. (2014). Stochastic integration on the real line. Theory of Probability and Its Applications, 58(2), 193-213. https://doi.org/10.1137/S0040585X97986540

Nam, K., Munch, K., Hobolth, A., Y. Dutheil, J., Veeramah, K., Woerner, A., F. Hammer, M., Ape Genome Diversity Project, G., Mailund, T. & H. Schierup, M. (2014). Strong selective sweeps associated with ampliconic regions in great ape X chromosomes. ArXiv.

Lyons, J. A., Parker, J. L., Solcan, N., Brinth, A., Li, D., Shah, S. T., Caffrey, M. & Newstead, S. (2014). Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Reports, 15(8), 886-893. https://doi.org/10.15252/embr.201338403

Ling, M., Santl-Temkiv, T., Finster, K. & Boesen, T. (2014). Structural studies of bacterial ice nucleation proteins and their relevance for atmospheric processes. Poster session presented at 2nd Ice Binding Conference, Sapporo, Japan.

Zhang, S., Jiang, Z., Besenbacher, F. & Dong, M. (2014). Study Sub-Membrane Structure and Corresponding Functions of Conductive Bacteria Cable by SPMs. Biophysical Journal, 106(2), 799A-799A.

Mian Teo, B., Lynge, M. E., Rigau, L. H. & Stadler, B. M. (2014). Subcompartmentalized Surface-Adhering Polymer Thin Films Toward Drug Delivery Applications. In Layer-by-Layer Films for Biomedical Applications Wiley.

Hornekær, L., Price, S. D., Mccoustra, M., Collings, M., Dulieu, F., Fillion, J. H., Palumbo, M. E., Ioppolo, S., Öberg, K. I., Linnartz, H. & Herbst, E. (2014). Surface Science. In Laboratory Astrochemistry: From Molecules through Nanoparticles to Grains (pp. 255-325). Wiley. https://doi.org/10.1002/9783527653133.ch5

Rosen, C. B., Kodal, A. L. B., Nielsen, J. S., Schaffert, D. H., Scavenius, C., Okholm, A. H., Voigt, N. V., Enghild, J. J., Kjems, J., Tørring, T. & Gothelf, K. V. (2014). Template-directed covalent conjugation of DNA to native antibodies, transferrin and other metal-binding proteins. Nature Chemistry, 6(9), 804-809. https://doi.org/10.1038/nchem.2003

Hyldgaard, M., Mygind, T., Vad, B. S., Stenvang, M., Otzen, D. & Meyer, R. L. (2014). The Antimicrobial Mechanism of Action of Epsilon-Poly-L-Lysine. Applied and Environmental Microbiology, 80(24), 7758-7770 . https://doi.org/10.1128/AEM.02204-14

Whitehead, B. J., Hvam, M. L., Bienk, K., Ostenfeld, M. S. & Howard, K. (2014). The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution. Poster session presented at The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States.

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Kalinka Hansen